The vector of anti-CD70 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD70. The T cells are genetically modified through transduction with a retroviral vector expressing CD19t and CD27 linked to CD3ζ signaling domain. This truncated CD19 can be used to select and track transducted T cells. And the vector product was designed for the treatment of non-Hodgkin lymphoma.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-T-2-L405-8Z||CD70 h(CD8-CD3ζ) CAR, [T]|
|CAR-T-1-L405-2||CD70 h(CD28) CAR, [T]|
|CAR-T-1-L405-G||CD70 h(FcεRIγ) CAR, [T]|
|CAR-T-2-L405-2Z||CD70 h(CD28-CD3ζ) CAR, [T]|
|CAR-T-2-L405-CZ||CD70 h(b2c-CD3ζ) CAR, [T]|
|CAR-T-3-L405-2BZ||CD70 h(CD28-41BB-CD3ζ) CAR, [T]|
|CAR-T-2-L405-4Z||CD70 h(CD4-CD3ζ) CAR, [T]|
|CAR-T-2-L405-4G||CD70 h(CD4-FcεRIγ) CAR, [T]|
|CAR-T-1-L405-Z||CD70 h(CD3ζ) CAR, [T]|
|CAR-T-3-L405-2XZ||CD70 h(CD28-OX40-CD3ζ) CAR, [T]|
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