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Anti-PA T cell receptor (6218), pCDTCR1 (TCR-C207Z)

The vector of anti-PA T cell receptor (TCR) is constructed for the engineering of T cell to target IAV PA. The T cells are genetically modified through transduction with a lentiviral vector expressing PA-specific T cell receptor. And the vector product was designed for the treatment of Influenza.

Details

  • Target
  • PA
  • Target Species
  • IAV
  • Epitope
  • SSLENFRAYV
  • Format
  • Chimeric
  • HLA
  • HLA-DB
  • Targeting Diseases
  • Influenza
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • 6218
  • Antibody Host
  • Chimeric

Target

  • Gene Name
  • Polymerase acidic protein
  • Official Symbol
  • PA
  • Synonyms
  • PA; Polymerase acidic protein
  • Introduction
  • Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity. In addition of its function in viral transcription, PA also plays an essential role in viral RNA synthesis and promotes the formation of the trimeric polymerase complex.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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