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pCDCAR1 CLD18A2 h(CD3ζ)(CAR-LC199)

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The vector of anti-CLD18A2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CLD18A2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CLD18A2 antibody linked to CD3ζ signaling domain. And the vector product was designed for the treatment of pancreatic cancer and gastric cancer.

Details

Target
CLDN18A2
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Pancreatic cancer, Gastric cancer
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Lentiviral
Receptor Construction
scFv-CD3ζ
Discription of Signaling Cassetes
CD3ζ
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
Antibody Clone
163
Antibody Host
Mouse

Target

Gene Name
Claudin 18
Official Symbol
CLDN18A2
Gene ID
51208
Synonyms
CLDN18; claudin 18; SFTA5; SFTPJ

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat# Description
CAR-LC201 Anti-CLD18A2 (175) h(CD3ζ) CAR, pCDCAR1
CAR-LC202 Anti-CLD18A2 (175) h(CD28-41BB-CD3ζ) CAR, pCDCAR1
CAR-LC200 Anti-CLD18A2 (163) h(CD28-41BB-CD3ζ) CAR, pCDCAR1

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CONTACT US
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USA: 1-631-381-2994
Europe: 44-207-097-1828
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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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