The vector of anti-EGFR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFR. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFR antibody linked to 4-1BB (CD137) and CD3ζ signaling domain. And the vector product was designed for the treatment of melanoma.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-LC100||Anti-EGFR (806) h(CD28-41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC777||Lenti-EGFRvIII CAR (scFv-CD3ζ, 3C10) Viral Particle|
|VP-CAR-LC785||Lenti-EGFRvIII CAR (scFv-41BB-CD3ζ, L8A4) Viral Particle|
|CAR-MZ009||Anti-EGFR (Nimotuzumab) h(CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC198||Lenti-EGFRvIII CAR (scFv-FcεRIγ, RAbDMvIII) Viral Particle|
|VP-CAR-LC781||Lenti-EGFRvIII CAR (scFv-CD3ζ, MR-1) Viral Particle|
|VP-CAR-LC780||Lenti-EGFRvIII CAR (scFv-CD28-OX40-CD3ζ, 3C10) Viral Particle|
|VP-CAR-LC194||Lenti-EGFR CAR (scFv-CD28-CD3ζ) Viral Particle|
|VP-CAR-LC208||Lenti-EGFRvIII CAR (scFv-CD28-OX40-CD3ζ, RAbDMvIII) Viral Particle|
|CAR-MZ005||Anti-EGFR (Cetuximab) h(CD3ζ) CAR, pCDCAR1|
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