The vector of anti-EGFR chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFR. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-EGFR antibody linked to CD3-zeta signaling domain. The CAR carrying an intracellular domain of a GITR tends to exhibit a higher cytokine production amount relative to the expression amount of the CAR. And the vector product was designed for the treatment of breast cancer.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC586||Lenti-EGFR CAR (scFv-CD28-CD3ζ, 806) Viral Particle|
|VP-CAR-LC792||Lenti-EGFRvIII CAR (scFv-CD28-41BB-CD3ζ, 131) Viral Particle|
|OAdCmodV-YX0679||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ24/55k, Anti-EGFR-6), Viral particle|
|CAR-MZ075||Anti-EGFRvIII (L8A4) h(CD28-41BB-CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC863||Lenti-EGFRvIII CAR (scFv-41BB-CD3ζ, 225) Viral Particle|
|OAdCmodV-YX0605||Oncolytic Adenovirus (Capsid modified Ad5, pCMV-Δ55k, Anti-EGFR-4), Viral particle|
|CAR-MZ009||Anti-EGFR (Nimotuzumab) h(CD3ζ) CAR, pCDCAR1|
|VP-CAR-LC859||Lenti-EGFR CAR (scFv-CD28-CD3ζ, R1) Viral Particle|
|VP-CAR-LC752||Lenti-EGFRvIII CAR (scFv-ICOS-CD3ζ, RAbDMvIII) Viral Particle|
|OAdCmodV-YX0676||Oncolytic Adenovirus (Capsid modified Ad5, phTERT-Δ24/55k, Anti-EGFR-3), Viral particle|
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