pCDCAR5 FOLH1 h(PD1)(CAR-LC385)

The vector of anti-PSMA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PSMA. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-PSMA antibody linked to PD-1 inhibitory signaling domains. And the vector product was designed for the treatment of prostate cancer.


Details


Target
PSMA
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
Prostate cancer
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-PD1
Antibody Clone
HuJ591
Antibody Host
Human

Target


Gene Name
folate hydrolase (prostate-specific membrane antigen) 1
Official Symbol
FOLH1
Gene ID
Synonyms
FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALAdase; glutamate carboxypeptidase 2; NAALADase I; glutamate carboxylase II; glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; cell growth-inhibiting gene 27 protein; folylpoly-gamma-glutamate carboxypeptidase; prostate specific membrane antigen variant F; pteroylpoly-gamma-glutamate carboxypeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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