pCDCAR1 GD2 h(DAP10)(CAR-MZ003)

The vector of anti-GD2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human GD2. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-GD2 antibody linked to DAP10 signaling domains. And the vector product was designed for the treatment of GD2 positive cancers.


Details


Target
GD2
Target Species
Human
Targeting Cell Type
T cell
Targeting Diseases
GD2 positive cancers
Generation
First
Vector Name
pCDCAR1
Vector Length
~8kb
Vector Type
Retroviral
Receptor Construction
scFv-DAP10
Discription of Signaling Cassetes
DAP10
DNAX-activating protein 10 (DAP10) is a transmembrane adaptor protein for natural killer group 2, member D (NKG2D), directly binds to RAGE and modulates the S100A8/A9-triggered signaling pathway. DAP10 as well as S100A8/A9 and RAGE were overexpressed in psoriatic epidermis.
Antibody Host
Human

Target


Gene Name
Graves disease, susceptibility to, 2
Official Symbol
GRD2
Gene ID
Synonyms
GD2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-048-3343

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