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Anti-Bob1 T cell receptor (3C10), pCDTCR1 (TCR-C015Z)

The vector of anti-Bob1 T cell receptor (TCR) is constructed for the engineering of T cell to target Human Bob1. The T cells are genetically modified through transduction with a lentiviral vector expressing Bob1-specific T cell receptor. And the vector product was designed for the treatment of Multiple myeloma.

Details

  • Target
  • Bob1
  • Target Species
  • Human
  • Epitope
  • YALNHTLSV
  • Format
  • Codon optimized
  • HLA
  • HLA-A*0201
  • Targeting Diseases
  • Multiple myeloma
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • 3C10
  • Antibody Host
  • Human

Target

  • Gene Name
  • POU class 2 associating factor 1
  • Official Symbol
  • POU2AF1
  • Synonyms
  • BOB1; OBF1; OCAB; OBF-1; POU2AF1; POU class 2 associating factor 1
  • Introduction
  • Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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