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Anti-BZLF1 T cell receptor (SB47), pCDTCR1 (TCR-C019Z)

The vector of anti-BZLF1 T cell receptor (TCR) is constructed for the engineering of T cell to target EBV BZLF1. The T cells are genetically modified through transduction with a lentiviral vector expressing BZLF1-specific T cell receptor. And the vector product was designed for the treatment of EBV infection.

Details

  • Target
  • BZLF1
  • Target Species
  • EBV
  • Epitope
  • LPEPLPQGQLTAY
  • Format
  • Codon optimized
  • HLA
  • HLA-B*3505
  • Targeting Diseases
  • EBV infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • Antibody Clone
  • SB47
  • Antibody Host
  • Human

Target

  • Gene Name
  • Trans-activator protein BZLF1
  • Official Symbol
  • BZLF1
  • Synonyms
  • BZLF1; Trans-activator protein BZLF1; EB1
  • Introduction
  • Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1).

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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