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Anti-MAGE-A4 T cell receptor (Codon optimized) (2-28), pCDTCR1 (TCR-C131Z)

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-MAGE-A4 T cell receptor (TCR) is constructed for the engineering of T cell to target Human MAGE-A4. The T cells are genetically modified through transduction with a lentiviral vector expressing MAGE-A4-specific T cell receptor. And the vector product was designed for the treatment of Esophageal cancer.

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Details

  • Target
  • MAGE-A4
  • Target Species
  • Human
  • Epitope
  • NYKRCFPVI
  • Format
  • Codon optimized
  • Allele
  • HLA-A*2402
  • Targeting Diseases
  • Esophageal cancer
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Clone
  • 2-28
  • Host Species
  • Human

Target

  • Official Symbol
  • MAGEA4
  • Introduction
  • This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

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