Anti-Nef T cell receptor (C1-28), pCDTCR1(TCR-C171Z)

The vector of anti-Nef T cell receptor (TCR) is constructed for the engineering of T cell to target HIV-1 Nef. The T cells are genetically modified through transduction with a lentiviral vector expressing Nef-specific T cell receptor. And the vector product was designed for the treatment of HIV-1 infection.


Details


Target
Nef
Target Species
HIV-1
Epitope
RYPLTFGWCF
Format
Non-modified
HLA
HLA-A24
Targeting Diseases
HIV-1 infection
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
C1-28
Antibody Host
Human

Target


Gene Name
p27
Official Symbol
Nef
Synonyms
CTAG1A; CT6.1; CTAG; Cancer/Testis Antigen 6.1; Cancer/Testis Antigen 1; Autoimmunogenic Cancer/Testis Antigen NY-ESO-1; CTAG1; LAGE2A; TCR; T cell receptor; transgenic TCR; antigen-specific T cell receptors; Engineering T-cell receptors; recombinant t cell receptors; specific t cell receptor; modified t cell receptor; retroviral vector; Melanoma
Introduction
The HIV Nef protein is a multifunctional virulence factor that perturbs intracellular membranes and signalling and is secreted into exosomes. While Nef-containing exosomes have a distinct proteomic profile, no comprehensive analysis of their miRNA cargo has been carried out. Since Nef functions as a viral suppressor of RNA interference and disturbs the distribution of RNA-induced silencing complex proteins between cells and exosomes, we hypothesized that it might also affect the export of miRNAs into exosomes.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
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