In Vivo Metabolism targeted Therapeutic Evaluation Services

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Unlocking the Therapeutic Power of Metabolic Modulation In Vivo

Tumors create a metabolic warzone that starves and disables CD8⁺ T cells - the very immune soldiers sent to destroy them. This nutrient deprivation leads to:

Frustrated killers (loss of cytotoxic punch)
Short-lived responders (failed memory formation)
Exhausted defenders (PD-1+ TIM-3+ phenotypes)

Our Solution: Creative Biolabs' in vivo testing platform recreates these challenges to:

Map metabolic barriers in different tumor types
Test protective interventions for T cells
Measure real-world outcomes: Tumor infiltration depth; Long-term persistence; Memory cell generation.

Our platform bridges the gap between in vitro findings and clinical relevance by providing data derived from physiologically relevant animal models. With expertise in T cell biology and immunometabolism, our team delivers reliable insights into how metabolic interventions modulate CD8⁺ T cell behavior in the context of living systems.

Service Portfolio: Core Assays and Analytical Modules

Custom Animal Model Development Service

We build customized murine models that closely reflect the metabolic and immunological conditions of human tumors. Our service includes syngeneic tumor models, humanized mouse models, and genetically engineered strains that allow for dynamic metabolic manipulation. These platforms support the assessment of metabolism-targeted drugs, genetically modified T cells, or engineered constructs under immune-relevant settings.

Memory T Cell Function Assay Service

Memory T cells are critical for sustained tumor control and long-term immunity. We offer detailed profiling of central memory (T_CM) and effector memory (T_EM) subsets post-treatment, evaluating their proliferation, homing, and recall response following antigenic re-challenge. This service provides a readout of therapeutic durability from a metabolic programming perspective.

Effector T Cell Function Assay Service

To assess short-term anti-tumor activity, we measure effector CD8⁺ T cell responses within tumors and peripheral tissues. Endpoints include cytokine production (e.g., IFN-γ, TNF-α), degranulation markers (CD107a), cytotoxic molecule expression (perforin, granzyme B), and metabolic readouts such as mitochondrial function and glycolytic capacity. These data help determine how metabolism-altering strategies influence immediate T cell efficacy in vivo.

Why Choose Creative Biolabs: Our Key Strengths

Immunometabolic Expertise: Our team has a strong foundation in both immunology and metabolic engineering, allowing us to interpret subtle functional shifts driven by metabolic reprogramming.

Validated In Vivo Models: We use well-characterized models to simulate real immunotherapeutic challenges, improving the translational relevance of your results.

Customizable Assay Design: We tailor all service modules based on your therapeutic platform, metabolic targets, and mechanistic hypotheses.

High-Resolution Readouts: Advanced flow cytometry, tissue imaging, and multiplexed assays provide deep insights into T cell dynamics across compartments.

Service Workflow: From Design to Data Delivery

Fig.1 Workflow. (Creative Biolabs Original)

Partner with Creative Biolabs for Reliable In Vivo Insights

When you collaborate with Creative Biolabs, you gain access to a scientific partner committed to your success. We support your project from the initial strategy meeting through data interpretation and next-step recommendations. Whether your goal is to validate a metabolic checkpoint inhibitor or characterize the persistence of metabolically engineered T cells, we're equipped to help you navigate the complex biology of in vivo systems with clarity and precision.

Frequently Asked Questions

Q1: Which mouse models can you use for my study?

A1: Our standard toolbox includes:

C57BL/6 - Gold standard for syngeneic tumor studies
BALB/c - Preferred for many immunotherapy models
Need specialized hosts? We also regularly work with: NOG/NSG mice for human cell engraftment; Custom genetically-modified strains.

Q2: Can I submit my own engineered T cells or therapeutic agent?

A2: Absolutely. We routinely work with client-supplied T cells, CAR-T products, antibodies, or small-molecule candidates for evaluation.

Q3: What types of metabolic interventions can be studied?

A3: We support evaluation of metabolic checkpoint blockade, mitochondrial enhancement strategies, glycolysis modulators, and more.

Contact Us

For inquiries about our In Vivo Metabolism Targeted Therapeutic Evaluation Services or to schedule a consultation with one of our immunometabolism specialists, reach out today. Let Creative Biolabs help bring your metabolic immunotherapy concepts to life—through the lens of rigorous in vivo science.

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.