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Lenti-B7-H4 CAR (scFv-28ζ, 56)-VP (VP-CAR-LC709)

The ready-to-use lentiviral particles of Lenti-B7-H4 CAR (scFv-28ζ, 56)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (56)--CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • B7-H4
  • Expression Cassette
  • scFv (56)--CD28-CD3ζ
  • Clone
  • 56
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Ovarian cancer

Target

  • Introduction
  • This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Alternative Names
  • VTCN1; V-set domain containing T-cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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