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B7-H4

B7-H4 also know as V-set domain-containing T-cell activation inhibitor 1(VTCN1), is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, making B7-H4 an attractive candidate for therapeutic intervention.

Associated Disease
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-ZP8418 Anti-B7-H4 (5F6) h(CD28-CD3ζ) CAR, pCDCAR1 Human 5F6 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8419 Anti-B7-H4 (5F6) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 5F6 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8420 Anti-B7-H4 (MAb11) h(CD28-CD3ζ) CAR, pCDCAR1 Human MAb11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8421 Anti-B7-H4 (MAb11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human MAb11 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8422 Anti-B7-H4 (MAb43) h(CD28-CD3ζ) CAR, pCDCAR1 Human MAb43 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8423 Anti-B7-H4 (MAb43) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human MAb43 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8424 Anti-B7-H4 (Sc209) h(CD28-CD3ζ) CAR, pCDCAR1 Human Sc209 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8425 Anti-B7-H4 (Sc209) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human Sc209 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8426 Anti-B7-H4 (Scl89) h(CD28-CD3ζ) CAR, pCDCAR1 Human Scl89 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8427 Anti-B7-H4 (Scl89) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human Scl89 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8428 Anti-B7-H4 (Sc77) h(CD28-CD3ζ) CAR, pCDCAR1 Human Sc77 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8429 Anti-B7-H4 (Sc77) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human Sc77 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8430 Anti-B7-H4 (278M1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 278M1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8431 Anti-B7-H4 (278M1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 278M1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8432 Anti-B7-H4 (278M1L2H2) h(CD28-CD3ζ) CAR, pCDCAR1 Human 278M1L2H2 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8433 Anti-B7-H4 (278M1L2H2) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 278M1L2H2 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8434 Anti-B7-H4 (NJI54) h(CD28-CD3ζ) CAR, pCDCAR1 Human NJI54 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8435 Anti-B7-H4 (NJI54) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human NJI54 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8436 Anti-B7-H4 (2H7) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2H7 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8437 Anti-B7-H4 (2H7) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2H7 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8438 Anti-B7-H4 (1H11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1H11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8439 Anti-B7-H4 (1H11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 1H11 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8440 Anti-B7-H4 (2D1) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2D1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8441 Anti-B7-H4 (2D1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2D1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8442 Anti-B7-H4 (2H9) h(CD28-CD3ζ) CAR, pCDCAR1 Human 2H9 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8443 Anti-B7-H4 (2H9) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 2H9 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8444 Anti-B7-H4 (1H3) h(CD28-CD3ζ) CAR, pCDCAR1 Human 1H3 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8445 Anti-B7-H4 (1H3) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 1H3 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8446 Anti-B7-H4 (12D11) h(CD28-CD3ζ) CAR, pCDCAR1 Human 12D11 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8447 Anti-B7-H4 (12D11) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 12D11 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8448 Anti-B7-H4 (A57.1) h(CD28-CD3ζ) CAR, pCDCAR1 Human A57.1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8449 Anti-B7-H4 (A57.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human A57.1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8450 Anti-B7-H4 (bs-0673R) h(CD28-CD3ζ) CAR, pCDCAR1 Human bs-0673R Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8451 Anti-B7-H4 (bs-0673R) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human bs-0673R Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8452 Anti-B7-H4 (3C8) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3C8 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8453 Anti-B7-H4 (3C8) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 3C8 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8454 Anti-B7-H4 (EP1165) h(CD28-CD3ζ) CAR, pCDCAR1 Human EP1165 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8455 Anti-B7-H4 (EP1165) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human EP1165 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8458 Anti-B7-H4 (hH4.1) h(CD28-CD3ζ) CAR, pCDCAR1 Human hH4.1 Mouse scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-ZP8459 Anti-B7-H4 (hH4.1) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human hH4.1 Mouse scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet

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