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B7-H4

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B7-H4 also know as V-set domain-containing T-cell activation inhibitor 1(VTCN1), is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, making B7-H4 an attractive candidate for therapeutic intervention.

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LC237 Anti-B7-H4 (56) h(-CD28-CD3ζ) CAR, pCDCAR1 Human 56 Human scFv--CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC238 Anti-B7-H4 (26) h(-CD28-CD3ζ) CAR, pCDCAR1 Human 26 Human scFv--CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC239 Anti-B7-H4 (54) h(-CD28-CD3ζ) CAR, pCDCAR1 Human 54 Human scFv--CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
XS-0822-YF913 Anti-Human B7-H4 (XW-913) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-913 Human scFv-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF1833 Anti-Human B7-H4 (XW-913) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-913 Human scFv-CD28-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0822-YF2753 Anti-Human B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT Human XW-913 Human scFv-CD28-41BB-CD3ζ In Vitro Transcription (IVT) Vector   Add to Cart   Datasheet
XS-0922-ZP1071 Anti-B7-H4 (3#68) h(CD28-CD3ζ) CAR, pCDCAR1 Human 3#68 Human scFv-CD28-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-0922-ZP1381 Anti-B7-H4 (3#68) h(4-1BB-CD3ζ) CAR, pCDCAR1 Human 3#68 Human scFv-4-1BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1122-YF913 Anti-B7-H4 KIR CAR (scFv-KIR2DS2-DAP12, XW-913), pCDCAR1 Human XW-913 Human scFv-KIR2DS2 TM&ICD-2A-DAP12 Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF1833 Anti-B7-H4 TCR-ABR (scFv-TCRα, XW-913) CAR Plasmid, pCDCAR1 Human XW-913 Human scFv-TCRα Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF2753 Anti-B7-H4 TCR-ABR (scFv-TCRβ, XW-913) CAR Plasmid, pCDCAR1 Human XW-913 Human scFv-TCRβ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF3673 Anti-B7-H4 TCR-ABR (scFv-CD3γ, XW-913) CAR Plasmid, pCDCAR1 Human XW-913 Human scFv-CD3γ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF4593 Anti-B7-H4 TCR-ABR (scFv-CD3δ, XW-913) CAR Plasmid, pCDCAR1 Human XW-913 Human scFv-CD3δ Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF5513 Anti-B7-H4 TCR-ABR (scFv-CD3ε, XW-913) CAR Plasmid, pCDCAR1 Human XW-913 Human scFv-CD3ε Lentiviral vector T Cell   Add to Cart   Datasheet
XS-1122-YF6433 Anti-B7-H4 (XW-913) h(CD28-CD3ζ) CAR, pAAV Human XW-913 Human scFv-CD28-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF7353 Anti-B7-H4 (XW-913) h(41BB-CD3ζ) CAR, pAAV Human XW-913 Human scFv-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-1122-YF8273 Anti-B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR, pAAV Human XW-913 Human scFv-CD28-41BB-CD3ζ Adeno-associated viral (AAV) vector T Cell   Add to Cart   Datasheet
XS-0123-ZP784 Anti-B7-H4 (3#68) h(scFv-CD3ε) TRuC, pCDTRC1 Human 3#68 Human scFv-CD3ε Lentiviral vector T cell   Add to Cart   Datasheet
XS-0323-ZP784 Anti-B7-H4 (3#68 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 Human 3#68 Human scFv-CD28TM-CD79β Lentiviral vector T cell CAR-B Vector   Add to Cart   Datasheet
XS-0923-LX107 Anti-hB7-H4 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector Human X9X-76 scFv-CD28-41BB-CD3ζ-duplex CTLA4 Lentiviral vector T cell CAR-T   Add to Cart   Datasheet
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