B7-H4

B7-H4 also know as V-set domain-containing T-cell activation inhibitor 1(VTCN1), is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, making B7-H4 an attractive candidate for therapeutic intervention.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC237 T cell Second 56 ~8kb Lentiviral scFv--CD28-CD3ζ Human Inquiry
CAR-LC238 T cell Second 26 ~8kb Lentiviral scFv--CD28-CD3ζ Human Inquiry
CAR-LC239 T cell Second 54 ~8kb Lentiviral scFv--CD28-CD3ζ Human Inquiry
CAR-LC240 T cell Second 68 ~8kb Lentiviral scFv--CD28-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC709 56 Lentivirus Second scFv (56)--CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC710 26 Lentivirus Second scFv (26)--CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC711 54 Lentivirus Second scFv (54)--CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC712 68 Lentivirus Second scFv (68)--CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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