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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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B7-H4 also know as V-set domain-containing T-cell activation inhibitor 1(VTCN1), is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, making B7-H4 an attractive candidate for therapeutic intervention.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC237 | Anti-B7-H4 (56) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 56 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC238 | Anti-B7-H4 (26) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 26 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC239 | Anti-B7-H4 (54) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 54 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-LC240 | Anti-B7-H4 (68) h(-CD28-CD3ζ) CAR, pCDCAR1 | Human | 68 | Human | scFv--CD28-CD3ζ | Lentiviral | T cell | ||
| XS-0822-YF913 | Anti-Human B7-H4 (XW-913) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1833 | Anti-Human B7-H4 (XW-913) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2753 | Anti-Human B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-913 | Human | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0922-ZP1071 | Anti-B7-H4 (3#68) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 3#68 | Human | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| XS-1122-YF913 | Anti-B7-H4 KIR CAR (scFv-KIR2DS2-DAP12, XW-913), pCDCAR1 | Human | XW-913 | Human | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1833 | Anti-B7-H4 TCR-ABR (scFv-TCRα, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2753 | Anti-B7-H4 TCR-ABR (scFv-TCRβ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF3673 | Anti-B7-H4 TCR-ABR (scFv-CD3γ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3γ | Lentiviral vector | T Cell | ||
| XS-1122-YF4593 | Anti-B7-H4 TCR-ABR (scFv-CD3δ, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3δ | Lentiviral vector | T Cell | ||
| XS-1122-YF5513 | Anti-B7-H4 TCR-ABR (scFv-CD3ε, XW-913) CAR Plasmid, pCDCAR1 | Human | XW-913 | Human | scFv-CD3ε | Lentiviral vector | T Cell | ||
| XS-1122-YF6433 | Anti-B7-H4 (XW-913) h(CD28-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-CD28-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF7353 | Anti-B7-H4 (XW-913) h(41BB-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-1122-YF8273 | Anti-B7-H4 (XW-913) h(CD28-41BB-CD3ζ) CAR, pAAV | Human | XW-913 | Human | scFv-CD28-41BB-CD3ζ | Adeno-associated viral (AAV) vector | T Cell | ||
| XS-0123-ZP784 | Anti-B7-H4 (3#68) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | 3#68 | Human | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0323-ZP784 | Anti-B7-H4 (3#68 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | 3#68 | Human | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0923-LX107 | Anti-hB7-H4 (CD28-41BB-CD3ζ) CAR-duplex CTLA4 pCDCAR1 Vector | Human | X9X-76 | scFv-CD28-41BB-CD3ζ-duplex CTLA4 | Lentiviral vector | T cell | CAR-T |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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