Lenti-B7H6 CAR (scFv-28BBζ, 47.39)-VP(VP-CAR-LC23)

The ready-to-use lentiviral particles of Lenti-B7H6 CAR (scFv-28BBζ, 47.39)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (47.39)-CD28-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
B7-H6
Expression Cassette
scFv (47.39)-CD28-41BB-CD3ζ
Clone
47.39
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Chronic lymphoid leukemia ( CLL )

Target


Introduction
B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
Alternative Names
B7H6; B7-H6; DKFZp686O24166; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; 47.39
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Leukemia

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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