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B7-H6

B7-H6 also called natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1), is a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. Interaction of B7H6 with NKp30 results in natural killer (NK) cell activation and cytotoxicity. B7-H6 was not detected in normal human tissues but was selectively expressed on a variety of human tumor cell lines, including T and B lymphomas, melanomas, and carcinomas. Furthermore, B7-H6 expression on tumor cells triggered NKp30-specific NK cell cytotoxicity and cytokine secretion. Thus, B7-H6 functions as a tumor-induced self-molecule that alerts in-nate immunity to cellular transformation via its interaction with the activating receptor NKp30.

Associated Disease
  • CAR Vector Products
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CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-L346-2 Anti-B7H6 scFv h(CD28) CART, pCDCAR1 Human 47.39 Mouse scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L346-G Anti-B7H6 scFv h(FcεRIγ) CART, pCDCAR1 Human 47.39 Mouse scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-L346-Z Anti-B7H6 scFv h(CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-2G Anti-B7H6 scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-2Z Anti-B7H6 scFv h(CD28-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-4G Anti-B7H6 scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-4Z Anti-B7H6 scFv h(CD4-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-8Z Anti-B7H6 scFv h(CD8-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-BZ Anti-B7H6 scFv h(41BB-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-L346-CZ Anti-B7H6 scFv h(b2c-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L346-2BZ Anti-B7H6 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-L346-2XZ Anti-B7H6 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human 47.39 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC349 Anti-NCR3LG1 (47.39) h(CD28-CD3ζ, CD19t) Marked CAR, pCDCAR1 Human 47.39 Mouse scFv-CD28-CD3ζ-T2A-CD19t Retroviral T cell   Add to Cart   Datasheet
CAR-MZ234 Anti-B7-H6, NKp30 receptor h(CD3ζ) CAR, pCDCAR1 Human Human NKp30 receptor-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ235 Anti-B7-H6, NKp30 receptor h(CD28TM-CD3ζ) CAR, pCDCAR1 Human Human NKp30-CD28TM-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ236 Anti-B7-H6, NKp30 receptor h(CD8αTM-CD3ζ) CAR, pCDCAR1 Human Human NKp30-CD8αTM-CD3ζ Retroviral T cell   Add to Cart   Datasheet
CAR-MZ237 Anti-B7-H6, NKp30 receptor h(CD28-CD3ζ) CAR, pCDCAR1 Human Human NKp30-CD28-CD3ζ Retroviral T cell   Add to Cart   Datasheet

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