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EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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B7-H6 also called natural killer cell cytotoxicity receptor 3 ligand 1 (NCR3LG1), is a member of the B7 family of immunoreceptors, is as a cell-surface ligand for the NKp30-activating receptor expressed on natural killer cells. Interaction of B7H6 with NKp30 results in natural killer (NK) cell activation and cytotoxicity. B7-H6 was not detected in normal human tissues but was selectively expressed on a variety of human tumor cell lines, including T and B lymphomas, melanomas, and carcinomas. Furthermore, B7-H6 expression on tumor cells triggered NKp30-specific NK cell cytotoxicity and cytokine secretion. Thus, B7-H6 functions as a tumor-induced self-molecule that alerts in-nate immunity to cellular transformation via its interaction with the activating receptor NKp30.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-L346-2 | Anti-B7H6 scFv h(CD28) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-L346-G | Anti-B7H6 scFv h(FcεRIγ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-L346-Z | Anti-B7H6 scFv h(CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L346-2G | Anti-B7H6 scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L346-2Z | Anti-B7H6 scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L346-4G | Anti-B7H6 scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-L346-4Z | Anti-B7H6 scFv h(CD4-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD4-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L346-8Z | Anti-B7H6 scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L346-BZ | Anti-B7H6 scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-L346-CZ | Anti-B7H6 scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-b2c-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L346-2BZ | Anti-B7H6 scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-L346-2XZ | Anti-B7H6 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell | ||
| CAR-LC349 | Anti-NCR3LG1 (XR41) h(CD28-CD3ζ, CD19t) Marked CAR, pCDCAR1 | Human | XR41 | Mouse | scFv-CD28-CD3ζ-T2A-CD19t | Retroviral | T cell | ||
| CAR-MZ234 | Anti-B7-H6, NKp30 receptor h(CD3ζ) CAR, pCDCAR1 | Human | Human | NKp30 receptor-CD3ζ | Retroviral | T cell | |||
| XS-1122-YF727 | Anti-B7-H6 KIR CAR (scFv-KIR2DS2-DAP12, XW-727), pCDCAR1 | Human | XW-727 | Mouse | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF728 | Anti-B7-H6 KIR CAR (scFv-KIR2DS2-DAP12, XW-728), pCDCAR1 | Human | XW-728 | Human | scFv-KIR2DS2 TM&ICD-2A-DAP12 | Lentiviral vector | T Cell | ||
| XS-1122-YF1647 | Anti-B7-H6 TCR-ABR (scFv-TCRα, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF1648 | Anti-B7-H6 TCR-ABR (scFv-TCRα, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-TCRα | Lentiviral vector | T Cell | ||
| XS-1122-YF2567 | Anti-B7-H6 TCR-ABR (scFv-TCRβ, XW-727) CAR Plasmid, pCDCAR1 | Human | XW-727 | Mouse | scFv-TCRβ | Lentiviral vector | T Cell | ||
| XS-1122-YF2568 | Anti-B7-H6 TCR-ABR (scFv-TCRβ, XW-728) CAR Plasmid, pCDCAR1 | Human | XW-728 | Human | scFv-TCRβ | Lentiviral vector | T Cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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