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Lenti-B7H6 CAR (scFv-28BBζ, 47.39)-VP (VP-CAR-LC23)

The ready-to-use lentiviral particles of Lenti-B7H6 CAR (scFv-28BBζ, 47.39)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (47.39)-CD28-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

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Specifications

  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • B7-H6
  • Expression Cassette
  • scFv (47.39)-CD28-41BB-CD3ζ
  • Clone
  • 47.39
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Chronic lymphoid leukemia ( CLL )

Target

  • Introduction
  • B7H6 belongs to the B7 family (see MIM 605402) and is selectively expressed on tumor cells. Interaction of B7H6 with NKp30 (NCR3; MIM 611550) results in natural killer (NK) cell activation and cytotoxicity (Brandt et al., 2009 [PubMed 19528259]).[supplied by OMIM, Jan 2011]
  • Alternative Names
  • B7H6; B7-H6; DKFZp686O24166; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv; 47.39

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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