Lenti-C2 CAR (scFv-28εRIγ, CIIC1; M2139)-VP(VP-CAR-LC40)
The ready-to-use lentiviral particles of Lenti-C2 CAR (scFv-28εRIγ, CIIC1; M2139)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (CIIC1; M2139)-CD28-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (CIIC1;M2139)-CD28-FcεRIγ
Packaging System
Lentivirus
Targeting Diseases
Autoimmune arthritis
Target
Introduction
Type II collagen is the basis for articular cartilage and hyaline cartilage.
It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage.
Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue.
Alternative Names
C2; type II collagen; autoimmune arthritis; arthritis; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; CIIC1; M2139;CIIC1; M2139
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Autoimmune Diseases
Datasheet
