Lenti-CD123 CAR (scFv-28OXζ, 7G3 )-VP(VP-CAR-LC292)

The ready-to-use lentiviral particles of Lenti-CD123 CAR (scFv-28OXζ, 7G3 )-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (7G3 )-CD28-OX40-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
CD123
Expression Cassette
scFv (7G3)-CD28-OX40-CD3ζ
Clone
7G3
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Acute myeloid leukaemia (AML)

Target


Introduction
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Alternative Names
IL3RA; interleukin 3 receptor, alpha (low affinity); IL3R; CD123; IL3RX; IL3RY; IL3RAY; hIL-3Ra; AML; acute myeloid leukaemia; leukaemia; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; 7G3
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Leukemia

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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