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Lenti-CD276 CAR (scFv-b2cζ, m851)-VP(VP-CAR-LC94)

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The ready-to-use lentiviral particles of Lenti-CD276 CAR (scFv-b2cζ, m851)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (m851)-b2c-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics
Chimeric Antigen Receptor
Target
CD276
Expression Cassette
scFv (m851)-b2c-CD3ζ
Clone
m851
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Chronic lymphocytic leukemia (CLL)

Target

Introduction
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3 UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Alternative Names
CD276; CD276 molecule; B7H3; B7-H3; B7RP-2; 4Ig-B7-H3; CD276 antigen; B7 homolog 3; costimulatory molecule; Chronic Lymphocytic Leukemia; CLL; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; m851; scFv
Gene ID
80381

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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USA: 1-631-381-2994
Europe: 44-207-097-1828
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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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