Lenti-EGFR/HER3 heterodimer CAR (scFv-28ζ)-VP (VP-CAR-LC665)

The ready-to-use lentiviral particles of Lenti-EGFR/HER3 heterodimer CAR (scFv-28ζ)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


  • Type of Therapeutics
  • Chimeric Antigen Receptor
  • Target
  • EGFR-HER3 heterodimer
  • Expression Cassette
  • scFv-CD28-CD3ζ
  • Promotor
  • EF1a
  • Packaging System
  • Lentivirus
  • Packaging Cell
  • 293T
  • Targeting Diseases
  • Breast cancer


  • Introduction
  • ErbB3 has an inactive kinase, and can be activated through heterodimerization by the other members of the family for signaling. HER3 as an allosteric activator of EGFR and revealed a conserved role of the allosteric mechanism in activation of HER family members through heterodimerization.
  • Alternative Names
  • EGFR/HER3 heterodimer

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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