All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
Members of the human epidermal growth factor receptor (HER) family of transmembrane receptor tyrosine kinases (HER1/EGFR; HER2; HER3; HER4) and their respective ligands constitute a robust biologic system that plays a key role in the regulation of cell-proliferative growth, survival, and differentiation. Ligand-bound monomeric HER receptors form homo- or heterodimers, which in turn activate their respective autokinase activities, leading to self-phosphorylation of c-terminus tyrosine residues serving as docking sites for adaptor proteins that activate downstream growth and survival signaling cascades. EGFR/HER3 heterodimer are potent activators of PI3K signaling, which in breast and other solid tumors, represents an important oncogenic signaling unit.
CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
CAR-LC182 | Anti-EGFR/HER3 heterodimer h(CD28-CD3ζ) CAR, pCDCAR1 | Human | Human | scFv-CD28-CD3ζ | Lentiviral | T cell | |||
CAR-LC183 | Anti-EGFR/HER3 heterodimer h(41BB-CD3ζ) CAR, pCDCAR1 | Human | Human | scFv-41BB-CD3ζ | Lentiviral | T cell |
The latest newsletter to introduce the latest breaking information, our site updates, field and other scientific news, important events, and insights from industry leaders
LEARN MORE NEWSLETTERCellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
LEARN MORE SOLUTIONSilence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
LEARN MORE NOVEL TECHNOLOGYCanine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
LEARN MORE SOLUTION