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EGFR-HER3 heterodimer

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

Members of the human epidermal growth factor receptor (HER) family of transmembrane receptor tyrosine kinases (HER1/EGFR; HER2; HER3; HER4) and their respective ligands constitute a robust biologic system that plays a key role in the regulation of cell-proliferative growth, survival, and differentiation. Ligand-bound monomeric HER receptors form homo- or heterodimers, which in turn activate their respective autokinase activities, leading to self-phosphorylation of c-terminus tyrosine residues serving as docking sites for adaptor proteins that activate downstream growth and survival signaling cascades. EGFR/HER3 heterodimer are potent activators of PI3K signaling, which in breast and other solid tumors, represents an important oncogenic signaling unit.

Associated Disease
  • CAR Vector Products

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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-LC182 Anti-EGFR/HER3 heterodimer h(CD28-CD3ζ) CAR, pCDCAR1 Human Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-LC183 Anti-EGFR/HER3 heterodimer h(41BB-CD3ζ) CAR, pCDCAR1 Human Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
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