EGFR-HER3 heterodimer

Members of the human epidermal growth factor receptor (HER) family of transmembrane receptor tyrosine kinases (HER1/EGFR; HER2; HER3; HER4) and their respective ligands constitute a robust biologic system that plays a key role in the regulation of cell-proliferative growth, survival, and differentiation. Ligand-bound monomeric HER receptors form homo- or heterodimers, which in turn activate their respective autokinase activities, leading to self-phosphorylation of c-terminus tyrosine residues serving as docking sites for adaptor proteins that activate downstream growth and survival signaling cascades. EGFR/HER3 heterodimer are potent activators of PI3K signaling, which in breast and other solid tumors, represents an important oncogenic signaling unit.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC182 T cell Second ~8kb Lentiviral scFv-CD28-CD3ζ Human Inquiry
CAR-LC183 T cell Second ~8kb Lentiviral scFv-41BB-CD3ζ Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC665 Lentivirus Second scFv-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC666 Lentivirus Second scFv-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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