Lenti-GD2 CAR (scFv-CD4εRIγ, ch14.18)-VP(VP-CAR-LC05)

The ready-to-use lentiviral particles of Lenti-GD2 CAR (scFv-CD4εRIγ, ch14.18)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (ch14.18)-CD4-FcεRIγ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
GD2
Expression Cassette
scFv (ch14.18)-CD4-FcεRIγ
Clone
ch14.18
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Neuroblastoma

Target


Introduction
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of G(M2) and G(D2) glycosphingolipids. GalNAc-T catalyzes the transfer of GalNAc into G(M3) and G(D3) by a beta-1,4 linkage, resulting in the synthesis of G(M2) and G(D2), respectively. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Alternative Names
B4GALNT1; beta-1,4-N-acetyl-galactosaminyl transferase 1; disialoganglioside; GALGT; SPG26; GALNACT; GalNAc-T; scFv; FcεRIγ; Chimeric antigen receptor; NK cell; Retrovirus; CARs; Lentivirus; chimeric NK cell receptors; chimeric immunoreceptors; chimeric antigen receptors; ch14.18
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Blastoma

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-048-3343

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