1. Home
  2. L1 cell adhesion molecule (L1-CAM)
  3. Lenti-L1 cell adhesion molecule(L1-CAM) CAR (scFv-41BB-CD3ζ, CE7) Viral Particle

Lenti-L1 cell adhesion molecule(L1-CAM) CAR (scFv-BBζ, CE7)-VP(VP-CAR-LC887)

DatasheetDatasheet

Online Inquiry

The ready-to-use lentiviral particles of Lenti-L1 cell adhesion molecule(L1-CAM) CAR (scFv-BBζ, CE7)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (CE7)-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.

Specifications

Type of Therapeutics
Chimeric Antigen Receptor
Target
L1 cell adhesion molecule (L1-CAM)
Expression Cassette
scFv (CE7)-41BB-CD3ζ
Clone
CE7
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
L1-CAM+ ovarian cancer

Target

Introduction
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
Alternative Names
L1CAM; L1 cell adhesion molecule; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; Metastatic neuroblastoma; neuroblastoma; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; CE7
Gene ID
3897

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Cat# Description
VP-CAR-LC886 Lenti-L1 cell adhesion molecule(L1-CAM) CAR (scFv-CD28-CD3ζ, CE7) Viral Particle
VP-CAR-LC306 Lenti-CD171 CAR (scFv-FcεRIγ, CE7) Viral Particle
CAR-T-2-M307-4Z Anti-CD171 scFv h(CD4-CD3ζ) CART, pCDCAR1
CAR-T-1-M307-G Anti-CD171 scFv h(FcεRIγ) CART, pCDCAR1
VP-CAR-LC316 Lenti-CD171 CAR (scFv-CD28-OX40-CD3ζ, CE7) Viral Particle
CAR-T-3-M307-2XZ Anti-CD171 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1
CAR-T-2-M307-CZ Anti-CD171 scFv h(b2c-CD3ζ) CART, pCDCAR1
VP-CAR-LC315 Lenti-CD171 CAR (scFv-CD28-41BB-CD3ζ, CE7) Viral Particle
CAR-T-2-M307-2G Anti-CD171 scFv h(CD28-FcεRIγ) CART, pCDCAR1
CAR-T-2-M307-2Z Anti-CD171 scFv h(CD28-CD3ζ) CART, pCDCAR1

OthersBlastoma Kits for CARs/TCRs Development 

Online Inquiry

Name:
* Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.
CB Promise
CONTACT US
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356
Email:
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

Distributors

To view the contact information for a specific location, select the desired country:

Australia
australia

FOLLOW US ON

Copyright © 2007 - 2018 Creative Biolabs. All Rights Reserved