Lenti-LeY CAR (scFv-28BBζ, 3S193)-VP(VP-CAR-LC327)
The ready-to-use lentiviral particles of Lenti-LeY CAR (scFv-28BBζ, 3S193)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (3S193)-CD28-41BB-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (3S193)-CD28-41BB-CD3ζ
Packaging System
Lentivirus
Targeting Diseases
LeY-expressing acute myeloid leukemia (AML)
Target
Introduction
The Lewis antigen system is a human blood group system based upon genes on chromosome 19 p13.3 (FUT3 or Lewis gene) and 19q13.3, (FUT2 or secretor gene). Both genes are expressed in glandular epithelia and have dominant alleles (Le and Se, respectively) coding for enzymes with fucosyltransferase activity and recessive alleles (le and se, respectively) that are not functional.
Alternative Names
LeY; Lewis Y; LeY; Lewis Y; Lewis a; Le-a; Lewis b; Le-b; LeY-expressing AML; cute myeloid leukaemia; leukaemia; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; 3S193
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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Leukemia
Kits for CARs/TCRs Development 
Datasheet
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