Lenti-MART-1(DMF5) CAR (scFv-CD8ζ, Melan-A)-VP(VP-CAR-LC336)

The ready-to-use lentiviral particles of Lenti-MART-1(DMF5) CAR (scFv-CD8ζ, Melan-A)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (Melan-A)-CD8-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
MART-1(DMF5)
Expression Cassette
scFv (Melan-A)-CD8-CD3ζ
Clone
Melan-A
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Metastatic melanoma

Target


Introduction
Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines.
Alternative Names
DMF5; MLANA; MART1; MART-1; metastatic melanoma; scFv; FcεRIγ; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; Melan-A
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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Carcinoma

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CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-097-1828

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