MART-1(DMF5)

Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines. The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known, this is the only one directly accessible to analysis in healthy individuals.

Associated Disease
  • Metastatic melanoma
  • Melanoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-M310-2 T cell First Melan-A 8kb Lentiviral scFv-CD28 Mouse and Human Inquiry
CAR-T-1-M310-G T cell First Melan-A 8kb Lentiviral scFv-FcεRIγ Mouse and Human Inquiry
CAR-T-1-M310-Z T cell First Melan-A 8kb Lentiviral scFv-CD3ζ Mouse and Human Inquiry
CAR-T-2-M310-2G T cell Second Melan-A 8kb Lentiviral scFv-CD28-FcεRIγ Mouse and Human Inquiry
CAR-T-2-M310-2Z T cell Second Melan-A 8kb Lentiviral scFv-CD28-CD3ζ Mouse and Human Inquiry
CAR-T-2-M310-4G T cell Second Melan-A 8kb Lentiviral scFv-CD4-FcεRIγ Mouse and Human Inquiry
CAR-T-2-M310-8Z T cell Second Melan-A 8kb Lentiviral scFv-CD8-CD3ζ Mouse and Human Inquiry
CAR-T-2-M310-BZ T cell Second Melan-A 8kb Lentiviral scFv-41BB-CD3ζ Mouse and Human Inquiry
CAR-T-2-M310-CZ T cell Second Melan-A 8kb Lentiviral scFv-b2c-CD3ζ Mouse and Human Inquiry
CAR-T-3-M310-2BZ T cell Third Melan-A 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse and Human Inquiry
CAR-T-3-M310-2XZ T cell Third Melan-A 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse and Human Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC329 Melan-A Lentivirus First scFv (Melan-A)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC330 Melan-A Lentivirus First scFv (Melan-A)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC331 Melan-A Lentivirus First scFv (Melan-A)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC332 Melan-A Lentivirus Second scFv (Melan-A)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC333 Melan-A Lentivirus Second scFv (Melan-A)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC334 Melan-A Lentivirus Second scFv (Melan-A)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC335 Melan-A Lentivirus Third scFv (Melan-A)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC336 Melan-A Lentivirus Second scFv (Melan-A)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC337 Melan-A Lentivirus Second scFv (Melan-A)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC338 Melan-A Lentivirus Second scFv (Melan-A)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC339 Melan-A Lentivirus Third scFv (Melan-A)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC340 Melan-A Lentivirus Third scFv (Melan-A)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
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Tel: 1-631-871-5806
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Email:

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Tel: 44-207-097-1828

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