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EXPLORE MORE HighlightsWe focus on unmet needs and develop novel cellular and gene drugs and solutions that offer significant benefits over existing options.
EXPLORE MORE HighlightsThe advent of Chimeric Antigen Receptor T-cell (CAR-T) therapies has revolutionized the field of oncology, providing new avenues for treating various forms of cancer. Our 20 years of experience in the biotechnology sector have equipped us with the expertise and technological capabilities to support the entire lifecycle of CAR-T products, from early development to commercialization.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines. The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known, this is the only one directly accessible to analysis in healthy individuals.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-T-1-M310-2 | Anti-MART-1(DMF5) scFv h(CD28) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28 | Lentiviral | T cell | ||
| CAR-T-1-M310-G | Anti-MART-1(DMF5) scFv h(FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-1-M310-Z | Anti-MART-1(DMF5) scFv h(CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-2G | Anti-MART-1(DMF5) scFv h(CD28-FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-M310-2Z | Anti-MART-1(DMF5) scFv h(CD28-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-4G | Anti-MART-1(DMF5) scFv h(CD4-FcεRIγ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD4-FcεRIγ | Lentiviral | T cell | ||
| CAR-T-2-M310-8Z | Anti-MART-1(DMF5) scFv h(CD8-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD8-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-BZ | Anti-MART-1(DMF5) scFv h(41BB-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-2-M310-CZ | Anti-MART-1(DMF5) scFv h(b2c-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-b2c-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-M310-2BZ | Anti-MART-1(DMF5) scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-41BB-CD3ζ | Lentiviral | T cell | ||
| CAR-T-3-M310-2XZ | Anti-MART-1(DMF5) scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 | Human | Melan-A | Mouse and Human | scFv-CD28-OX40-CD3ζ | Lentiviral | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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NOVEL TECHNOLOGY
Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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NEW SOLUTION
Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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