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MART-1(DMF5)

Protein melan-A also known as melanoma antigen recognized by T cells 1 or MART-1 is a protein that in humans is encoded by the MLANA or "MALENA" gene. A fragment of the protein, usually consisting of the nine amino acids 27 to 35, is bound by MHC class I complexes which present it to T cells of the immune system. These complexes can be found on the surface of melanoma cells. Decameric peptides (26-35) are being investigated as cancer vaccines. The self-antigen Melan-A/MART-1 is frequently involved in T-cell responses against malignant melanoma. The use of fluorescent tetramers incorporating the immunodominant Melan-A/MART-1 peptide has provided new insights into HLA-A2-restricted T-cell responses against this antigen in cancer patients and in healthy individuals. Direct evidence has been provided that a large Melan-A/MART-1-specific CD8 T-cell pool is generated during thymic selection. Although several other examples of naive self-peptide-specific T-cell repertoires are known, this is the only one directly accessible to analysis in healthy individuals.

Associated Disease
  • Metastatic melanoma
  • Melanoma
  • CAR Vector Products
  • CAR Viral Particles
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  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-M310-2 Anti-MART-1(DMF5) scFv h(CD28) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD28 Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M310-G Anti-MART-1(DMF5) scFv h(FcεRIγ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-1-M310-Z Anti-MART-1(DMF5) scFv h(CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-2G Anti-MART-1(DMF5) scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD28-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-2Z Anti-MART-1(DMF5) scFv h(CD28-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD28-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-4G Anti-MART-1(DMF5) scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD4-FcεRIγ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-8Z Anti-MART-1(DMF5) scFv h(CD8-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD8-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-BZ Anti-MART-1(DMF5) scFv h(41BB-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-2-M310-CZ Anti-MART-1(DMF5) scFv h(b2c-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-b2c-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M310-2BZ Anti-MART-1(DMF5) scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD28-41BB-CD3ζ Lentiviral T cell   Add to Cart   Datasheet
CAR-T-3-M310-2XZ Anti-MART-1(DMF5) scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human Melan-A Mouse and Human scFv-CD28-OX40-CD3ζ Lentiviral T cell   Add to Cart   Datasheet

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