Lenti-Mesothelin CAR (scFv-ζ, SS1)-VP(VP-CAR-LC355)
The ready-to-use lentiviral particles of Lenti-Mesothelin CAR (scFv-ζ, SS1)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (SS1)-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.
Specifications
Type of Therapeutics
Chimeric Antigen Receptor
Expression Cassette
scFv (SS1)-CD3ζ
Packaging System
Lentivirus
Targeting Diseases
Pancreatic cancer; ovarian cancer; lung cancer; malignant pleural mesothelioma tumors(MPM tumors)
Target
Introduction
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Alternative Names
MPF; SMRP
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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CarcinomaOncolytic VirusGerm Cell Tumor
Kits for CARs/TCRs Development 
Datasheet
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