Lenti-PSCA CAR (scFv-28ζ, 7F5)-VP(VP-CAR-LC852)

The ready-to-use lentiviral particles of Lenti-PSCA CAR (scFv-28ζ, 7F5)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (7F5)-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
PSCA
Expression Cassette
scFv (7F5)-CD28-CD3ζ
Clone
7F5
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
Prostate cancer

Target


Introduction
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Alternative Names
PSCA; prostate stem cell antigen; PRO232; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CarcinomaOthers

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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