Lenti-TR1 CAR (scFv-28ζ, TR404)-VP(VP-CAR-LC812)

The ready-to-use lentiviral particles of Lenti-TR1 CAR (scFv-28ζ, TR404)-VP is packaged using 3rd generation of lentiviral packaging system, in which the gene of CAR will be driven by a CMV promotor. The target gene of scFv (TR404)-CD28-CD3ζ packaged in lentiviral particles could be used for high efficency tranduction of T cells and stably integrated expression.


Specifications


Type of Therapeutics
Chimeric Antigen Receptor
Target
TR1
Expression Cassette
scFv (TR404)-CD28-CD3ζ
Clone
TR404
Promotor
CMV
Packaging System
Lentivirus
Packaging Cell
293T
Targeting Diseases
TR-expressing tumors

Target


Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Alternative Names
TNFRSF10A; tumor necrosis factor receptor superfamily; member 10a; DR4; APO2; CD261; TRAILR1; TRAILR-1; tumor necrosis factor receptor superfamily member 10A; TRAIL-R1; TRAIL receptor 1; death receptor 4; cytotoxic TRAIL receptor; TNF-related apoptosis-inducing ligand receptor 1; tumor necrosis factor receptor superfamily member 10a variant 2; anti-DR4
Gene ID

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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CONTACT US

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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

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Tel: 44-207-097-1828

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