Anti-pBM8 T cell receptor (BM3.3), pCDTCR1(TCR-C209Z)

The vector of anti-pBM8 T cell receptor (TCR) is constructed for the engineering of T cell to target Mouse pBM8. The T cells are genetically modified through transduction with a lentiviral vector expressing pBM8-specific T cell receptor.


Details


Target
pBM8
Target Species
Mouse
Epitope
SQYYYNSL
Format
Single-chain
HLA
H-2KbM8
Vector Name
pCDTCR1
Vector Length
~8kb
Vector Type
Lentiviral
Antibody Clone
BM3.3
Antibody Host
Mouse

Target


Gene Name
RNA-binding protein 5
Official Symbol
Rbm5
Gene ID
UniProt ID
Synonyms
RBM5; RNA-binding protein 5
Introduction
Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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