pBM8

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Associated Disease

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TCR-C209Z pBM8 Mouse BM3.3 Mouse ~8kb Lentiviral SQYYYNSL Single-chain H-2KbM8 Inquiry

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Animal
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System
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Price
VP-TCR-C467 Mouse BM3.3 Mouse Lentivirus SQYYYNSL Single-chain TCR > 10⁷ IFU/ml Inquiry
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