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pBM8

Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Caspase-2 that induces apoptosis.

Associated Disease
  • TCR Vector Products
  • TCR Viral Particles
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    CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
    TCR-C209Z Mouse anti-pBM8 T cell receptor (BM3.3), pCDTCR1 Mouse BM3.3 Mouse SQYYYNSL H-2KbM8 Lentiviral   Inquiry
      Datasheet

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