CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway.
Copyright © 2007 - 2018 Creative Biolabs. All Rights Reserved