Trh4

CerS5 robustly synthesizes C16-ceramide, which is often considered to be an important pro-apoptotic ceramide. De novo ceramide synthesis is an essential trigger for Bax activation in hypoxia/reoxygenation. Following hypoxia/reoxygenation, CerS5 expression is elevated. Upon knocking down acid sphingomyelinase and CerS5 in NTERA-2cells, Bax localization to mitochondria was reduced, indicating the importance of CerS5 activity in the apoptosis pathway.

Associated Disease
  • Cancer

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TCR-C253Z Trh4 Mouse LnB5 Mouse ~8kb Lentiviral MCLRMTAVM Non-modified H-2Db Inquiry

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VP-TCR-C038 Mouse LnB5 Mouse Lentivirus MCLRMTAVM Non-modified TCR > 10⁷ IFU/ml Inquiry
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