CellRapeutics™ Multiplex Cytokine & Chemokine Assay Service

Cytokines and chemokines play pivotal roles in orchestrating antitumor immunity by regulating T cell infiltration, survival, and differentiation within the tumor microenvironment. Creative Biolabs' CellRapeutics™ Multiplex Cytokine and Chemokine Assay Service offers a comprehensive, high-throughput solution capable of simultaneously quantifying multiple immune mediators with high sensitivity and reproducibility, surpassing the limitations of traditional single-analyte approaches. These data we provided supports the rational design of immunotherapies, identification of predictive biomarkers, and advancement of personalized cancer treatment strategies.

Introduction

Cytokines and chemokines function as pivotal regulatory mediators that orchestrate immune cell recruitment, activation, and functional polarization within the tumor microenvironment. They critically determine the efficacy of T cell infiltration, survival, and antitumor activity, thereby influencing both immune responsiveness and therapeutic outcomes. Given the complex, context-dependent nature of these signaling networks, multiplex cytokine and chemokine assays represent an essential tool for comprehensively profiling immune responses, identifying predictive biomarkers, and guiding the development of targeted immunotherapeutic strategies.

Fig.1 Intratumoral cytokine networks dictating T cell persistence and function.¹

CellRapeutics™ Multiplex Cytokine and Chemokine Assay Service at Creative Biolabs

Creative Biolabs' CellRapeutics™ Multiplex Cytokine and Chemokine Assay Service provides a comprehensive, high-throughput solution for the simultaneous quantification of multiple cytokines and chemokines. This multi-biomarker approach offers a significant advantage over traditional, single-plex assays by providing a holistic view of the immune response, which is crucial for understanding disease pathology, monitoring treatment efficacy, and identifying novel therapeutic targets.

What we can offer

Leveraging the critical function of cytokines and chemokines in cellular immune responses, Creative Biolabs has developed an advanced multiplex cytokine and chemokine profiling platform. This innovative solution enables simultaneous quantification of multiple immune mediators across diverse biological samples, supporting both fundamental research and clinical translation studies with high precision and efficiency.

Our Service Process

Required Starting Materials:

• Sample Type and Volume: Details on the biological matrix (such as serum, plasma, tissue homogenate, cell culture supernatant) and the required volume to ensure sufficient material for analysis.
• List of Target Analytes: A specific list of cytokines and chemokines to be quantified from our available panels.
• Project Goals: A brief description of the project's objective, such as diagnosing a specific disease, assessing a therapeutic's impact, or profiling an immune response.

Key steps:

Final Deliverables:

• A comprehensive data report containing raw analyte concentration values.
• Analyzed data files, including statistical summaries and graphical representations.
• A final project summary and recommendations based on the findings.

Key Advantage

• Comprehensive Multi-analytic Profiling: The CellRapeutics™ service supports simultaneous quantification of up to 50 cytokines and chemokines from a single sample, delivering a systems-level perspective on immune activity to enhance your research insights.
• Customizable Panel Design: With exceptional flexibility, researchers can tailor analyte selection from our broad repository of rigorously validated targets to construct bespoke panels that precisely address unique experimental requirements.
• Superior Data Quality and Reproducibility: Employing a robust microbead-based multiplex immunoassay platform, we ensure consistently high data reliability and reproducibility, extensively validated across a range of demanding biological matrices.

FAQ

Why Choose Us?

Founded on scientific excellence and technological innovation, our service delivers a holistic perspective beyond the limitations of single-analyte assays. Our multiplex platform has been clinically validated to provide enhanced diagnostic and prognostic power in areas including inflammatory diseases, neurology, and infectious disease research. We ensure reliable and reproducible performance across a wide spectrum of biological matrices, encompassing both standard specimens and challenging fluids.

Customer Reviews

" The implementation of Creative Biolabs' CellRapeutics™ in our studies has markedly enhanced the resolution of disease subtype discrimination, delivering insights unattainable with conventional assays. The data integrity was exceptional, complemented by outstanding technical support. " -Dr. C**e, Clinical Research Scientist.

"Creative Biolabs' platform substantially accelerated our project timeline while adhering to budget constraints. The assay demonstrated high reproducibility, a critical factor in our infectious disease diagnostics pipeline, leading to full adoption in place of discrete ELISA workflows." -Dr. A**r, Lab Director.

"Despite initial reservations regarding multiplex assay performance with complex sample types, Creative Biolabs validated its robustness in our hands. The resulting pathway-level inflammatory profiling proved pivotal to advancing our therapeutic program." -Dr. M**a, Senior Scientist.

How to contact us?

To explore how our services can accelerate the achievement of your specific research objectives, please contact our team for a detailed consultation.

Advance Your Research with Our Expertise.

Reference

1. Zhang, Yu et al. "Cytokine and Chemokine Signals of T-Cell Exclusion in Tumors." Frontiers in immunology vol. 11 594609. https://doi.org/10.3389/fimmu.2020.594609. Distributed under Open Access License CC BY 4.0, without modification.