The vector of anti-CD276 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD276. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD276 antibody linked to CD3-zeta and b2c signaling domains. And the vector product was designed for detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed, for example, chronic lymphocytic leukemia (CLL).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC646||Lenti-CD276 CAR (scFv-CD28-CD3ζ, CD276.17) Viral Particle|
|VP-CAR-LC87||Lenti-CD276 CAR (scFv-CD3ζ, m851) Viral Particle|
|CAR-T-2-L334-BZ||Anti-CD276 scFv h(41BB-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC92||Lenti-CD276 CAR (scFv-CD8-CD3ζ, m851) Viral Particle|
|CAR-T-2-L334-4Z||Anti-CD276 scFv h(CD4-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC95||Lenti-CD276 CAR (scFv-CD28-41BB-CD3ζ, m851) Viral Particle|
|CAR-T-2-L334-8Z||Anti-CD276 scFv h(CD8-CD3ζ) CART, pCDCAR1|
|CAR-T-3-L334-2XZ||Anti-CD276 scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC89||Lenti-CD276 CAR (scFv-CD28-CD3ζ, m851) Viral Particle|
|VP-CAR-LC94||Lenti-CD276 CAR (scFv-b2c-CD3ζ, m851) Viral Particle|
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