pCDCAR1 CD276 h(FcεRIγ), T (CAR-T-1-L334-G)

The vector of anti-CD276 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human CD276. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-CD276 antibody linked to FcεRIγ signaling domains. And the vector product was designed for detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed, for example, chronic lymphocytic leukemia (CLL).


  • Target
  • CD276
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Chronic lymphocytic leukemia (CLL)
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.
  • Antibody Clone
  • m851
  • Antibody Host
  • Human


  • Gene Name
  • CD276 Molecule
  • Official Symbol
  • CD276
  • Synonyms
  • CD276 Molecule; CD276 Antigen; Costimulatory Molecule; B7 Homolog 3; 4Ig-B7-H3; B7-H3; B7H3; B7RP-2;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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