pCDCAR1 EGFRvIII h(28), T(CAR-T-1-M315-2)
The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFRvIII. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to CD28 signaling domains. And the vector product was designed for the treatment of glioma.
Targeting Cell Type
Discription of Signaling Cassetes
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
Epidermal Growth Factor Receptor
Epidermal Growth Factor Receptor 2; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 22.214.171.124; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian); Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog; Cell Proliferation-Inducing Protein 61; Cell Growth Inhibiting Protein 40; EC 2.7.10; NISBD2; PIG61; MENA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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||Anti-EGFR (5BA23) h(CD28-CD3ζ) CAR, pCDCAR1
||Lenti-EGFRvA CAR (scFv-CD28-41BB-CD3ζ, 2D3) Viral Particle
||Anti-EGFR (806) h(CD3ζ) CAR, pCDCAR1
||Lenti-EGFR CAR (scFv-CD28-CD3ζ, 806) Viral Particle
||Anti-EGFRvIII (MR-1) h(CD3ζ) CAR, pCDCAR1
||Anti-EGFR (806) h(CD28-CD3ζ) CAR, pCDCAR1
||Anti-EGFRvIII (13.1.2) h(CD28-41BB-CD3ζ) CAR, pCDCAR1