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pCDCAR1 EGFRvIII h(28), T (CAR-T-1-M315-2)

The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human EGFRvIII. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to CD28 signaling domains. And the vector product was designed for the treatment of glioma.

Details

  • Target
  • EGFRvIII
  • Target Species
  • Human
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Glioma
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-CD28
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatorysignals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells(APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
  • Antibody Clone
  • RAbDMvIII
  • Antibody Host
  • Human

Target

  • Gene Name
  • Epidermal Growth Factor Receptor
  • Official Symbol
  • EGFR
  • Synonyms
  • C-erb; c-erbB; CG10079; D-Egf; d-egf-r; D-EGFR; degfr; dEgfr; dEGFr; dEGFR; Degfr; DEgfr; DEGFR; dEGFR1; der; Der; DER; DER flb; DER/EGFR; DER/top; DER/torpedo; DER1; Dmel\CG10079; DmHD-33; EC2-4; EFG-R; Egf; Egf-r; EGF-R; egfr; EgfR; EGfr; EGFr; EGFR; EK2-6; El; Elp; Elp-1; Elp-B1; Elp-B1RB1; flb; Flb; HD-33; l(2)05351; l(2)09261; l(2)57DEFa; l(2)57Ea; l(2)57EFa; mor1; top; Top; TOP; top/DER; top/flb; Tor; Torpedo/DER; torpedo/egfr; torpedo/Egfr; Torpedo/Egfr

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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