The vector of anti-κ light chain chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human κ light chain. The T cell is genetically modified through transduction with a lentiviral vector expressing scFv of anti-κ light chain antibody linked to CD8 hinge-transmembrane domain and CD3-zeta signaling domains. And the vector product was designed for the treatment of B cell-chronic lymphocytic leukemia (B-CLL).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-T-1-M403-2||κ light chain h(CD28) CAR, [T]|
|CAR-T-2-M403-4G||κ light chain h(CD4-FcεRIγ) CAR, [T]|
|CAR-T-2-M403-2Z||κ light chain h(CD28-CD3ζ) CAR, [T]|
|CAR-T-2-M403-4Z||κ light chain h(CD4-CD3ζ) CAR, [T]|
|CAR-T-1-M403-G||κ light chain h(FcεRIγ) CAR, [T]|
|CAR-T-2-M403-BZ||κ light chain h(41BB-CD3ζ) CAR, [T]|
|CAR-T-3-M403-2BZ||κ light chain h(CD28-41BB-CD3ζ) CAR, [T]|
|CAR-T-2-M403-2G||κ light chain h(CD28-FcεRIγ) CAR, [T]|
|VP-CAR-LC692||Lenti-Kappa light chain CAR (scFv-41BB-CD3ζ) Viral Particle|
|CAR-T-3-M403-2XZ||κ light chain h(CD28-OX40-CD3ζ) CAR, [T]|
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