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pCDCAR1 IL13Rα2 h(γ), T (CAR-T-1-M401-G)

The vector of anti-IL13Rα2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human IL13Rα2. The T cells are genetically modified through transduction with a lentiviral vector expressing IL13 linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of glioblasto mamultiforme (GBM)

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Details

  • Target
  • IL13Rα2
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • Glioblastoma multiforme (GBM)
  • Generation
  • First
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • scFv-FcεRIγ
  • Discription of Signaling Cassetes
  • FcεRIγ
    The high-affinity IgE receptor, also known as FcεRI, or Fc epsilon RI, is the high-affinity receptor for the Fc region of immunoglobulin E (IgE). FcεRI is a key molecule involved in allergic reactions. It is a tetramer composed of 1alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The scFv-based CARs engineered to contain a signaling domain from FcεRIγ have been shown to deliver a potent signal for T cell activation and function.

Target

  • Host
  • Human
  • Target Species
  • Human
  • Gene Name
  • Interleukin 13 Receptor Subunit Alpha 2
  • Gene ID
  • 3598
  • Synonyms
  • Interleukin 13 Receptor Subunit Alpha 2

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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