The vector of anti-LeY chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human LeY. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-LeY antibody linked to FcεRIγ signaling domains. And the vector product was designed for the treatment of LeY-expressing acute myeloid leukemia (AML).
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-T-2-M320-2G||Anti-LeY scFv h(CD28-FcεRIγ) CART, pCDCAR1|
|VP-CAR-LC318||Lenti-LeY CAR (scFv-FcεRIγ, 3S193) Viral Particle|
|CAR-T-2-M320-BZ||Anti-LeY scFv h(41BB-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC321||Lenti-LeY CAR (scFv-CD28-CD3ζ, 3S193) Viral Particle|
|CAR-T-3-M320-2XZ||Anti-LeY scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC323||Lenti-LeY CAR (scFv-CD4-CD3ζ, 3S193) Viral Particle|
|VP-CAR-LC319||Lenti-LeY CAR (scFv-CD3ζ, 3S193) Viral Particle|
|VP-CAR-LC320||Lenti-LeY CAR (scFv-CD28-FcεRIγ, 3S193) Viral Particle|
|VP-CAR-LC326||Lenti-LeY CAR (scFv-b2c-CD3ζ, 3S193) Viral Particle|
|VP-CAR-LC327||Lenti-LeY CAR (scFv-CD28-41BB-CD3ζ, 3S193) Viral Particle|
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