pCDCAR1 TAG-72 h(b2cζ), T (CAR-T-2-M551-CZ)

The vector of anti-TAG-72 chimeric antigen receptor(CAR) is constructed for the engineering of T cell to target human TAG-72. The T cell is genetically modified through transduction with a lentiviral vector expressing anti-TAG-72 VHH linked to b2c and CD3-zeta signaling domains. And the vector product was designed for the treatment of TAG-72 expressing tumor.

Datasheet   Add to Cart


  • Target
  • TAG-72
  • Targeting Cell Type
  • T cell
  • Targeting Diseases
  • TAG-72 expressing tumor
  • Generation
  • Second
  • Vector Name
  • pCDCAR1
  • Vector Length
  • 8kb
  • Vector Type
  • Lentiviral
  • Receptor Construction
  • VHH-b2c-CD3ζ
  • Discription of Signaling Cassetes
  • b2c
    The b2c protein belongs to high-sulphur keratin family which comprises at least three proteins, B2A, B2B and B2C. And b2c in chimeric antigen receptors improve T-cell effector functions and enhance anti-tumor activity.
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta,which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.


  • Clone
  • CC49
  • Host
  • Humanized
  • Target Species
  • Human
  • Gene Name
  • TAG-72
  • Synonyms
  • TAG-72;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Related Products

Online Inquiry


USA: 45-1 Ramsey Road, Shirley, NY 11967, USA
Europe: Heidenkampsweg 58, 20097 Hamburg, Germany
Call us at:
USA: 1-631-381-2994
Europe: 44-207-097-1828
Fax: 1-631-207-8356

Online Inquiry

For any technical issues or products/services related questions, please leave your information below. Our team will contact you soon.

  • Verification code
    Click image to refresh the verification code.

Key Updates

Receive our latest news and insights.