The vector of anti-VEGFR-2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target mouse VEGFR-2. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-VEGFR-2 antibody linked to CD3-zeta and b2c signaling domains. And the vector product was designed for detecting the presence of cancer in a host and treating or preventing cancer in a host are also disclosed, for example, diabetic retinopathy.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|CAR-T-2-L341-2G||Anti-VEGFR-2 scFv m(CD28-FcεRIγ) CART, pCDCAR1|
|CAR-T-2-L341-4G||Anti-VEGFR-2 scFv m(CD4-FcεRIγ) CART, pCDCAR1|
|VP-CAR-LC499||Lenti-VEGFR-2 CAR (scFv-CD3ζ, DC101) Viral Particle|
|CAR-T-3-L341-2BZ||Anti-VEGFR-2 scFv m(CD28-41BB-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC501||Lenti-VEGFR-2 CAR (scFv-CD28-CD3ζ, DC101) Viral Particle|
|VP-CAR-LC500||Lenti-VEGFR-2 CAR (scFv-CD28-FcεRIγ, DC101) Viral Particle|
|CAR-T-1-L341-Z||Anti-VEGFR-2 scFv m(CD3ζ) CART, pCDCAR1|
|VP-CAR-LC507||Lenti-VEGFR-2 CAR (scFv-CD28-41BB-CD3ζ, DC101) Viral Particle|
|CAR-T-2-L341-8Z||Anti-VEGFR-2 scFv m(CD8-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC498||Lenti-VEGFR-2 CAR (scFv-FcεRIγ, DC101) Viral Particle|
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