VEGFR-2

Vascular endothelial growth factor receptor 2 (VEGFR2) is a primary responder to vascular endothelial growth factor signal, and thereby regulates endothelial migration and proliferation. This receptor is expressed in endothelial cells and some vascular tumors, but many reports also detail its expression in carcinomas and lymphomas. VEGFR2 is a potential cell type marker, and data on VEGFR2 expression may also have therapeutic significance in view of recent availability of VEGFR2 inhibitors. As it directly upregulates tumor angiogenesis, VEGFR-2 is an appropriate target for suppression of solid tumor growth using exogenous antibodies, small inhibitory molecules and in vivo stimulation of the immune system.

Associated Disease

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-LC132 T cell Third KDR-1121 ~8kb Retroviral scFv-CD28-41BB-CD3ζ Human Inquiry
CAR-LC133 T cell Second KDR-1121 ~8kb Retroviral scFv-CD28-CD3ζ Human Inquiry
CAR-T-1-L341-2 T cell First DC101 8kb Lentiviral scFv-CD28 Rat Inquiry
CAR-T-1-L341-G T cell First DC101 8kb Lentiviral scFv-FcεRIγ Rat Inquiry
CAR-T-1-L341-Z T cell First DC101 8kb Lentiviral scFv-CD3ζ Rat Inquiry
CAR-T-2-L341-2G T cell Second DC101 8kb Lentiviral scFv-CD28-FcεRIγ Rat Inquiry
CAR-T-2-L341-2Z T cell Second DC101 8kb Lentiviral scFv-CD28-CD3ζ Rat Inquiry
CAR-T-2-L341-4G T cell Second DC101 8kb Lentiviral scFv-CD4-FcεRIγ Rat Inquiry
CAR-T-2-L341-4Z T cell Second DC101 8kb Lentiviral scFv-CD4-CD3ζ Rat Inquiry
CAR-T-2-L341-8Z T cell Second DC101 8kb Lentiviral scFv-CD8-CD3ζ Rat Inquiry
CAR-T-2-L341-BZ T cell Second DC101 8kb Lentiviral scFv-41BB-CD3ζ Rat Inquiry
CAR-T-2-L341-CZ T cell Second DC101 8kb Lentiviral scFv-b2c-CD3ζ Rat Inquiry
CAR-T-3-L341-2BZ T cell Third DC101 8kb Lentiviral scFv-CD28-41BB-CD3ζ Rat Inquiry
CAR-T-3-L341-2XZ T cell Third DC101 8kb Lentiviral scFv-CD28-OX40-CD3ζ Rat Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC497 DC101 Lentivirus First scFv (DC101)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC498 DC101 Lentivirus First scFv (DC101)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC499 DC101 Lentivirus First scFv (DC101)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC500 DC101 Lentivirus Second scFv (DC101)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC501 DC101 Lentivirus Second scFv (DC101)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC502 DC101 Lentivirus Second scFv (DC101)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC503 DC101 Lentivirus Second scFv (DC101)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC504 DC101 Lentivirus Second scFv (DC101)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC505 DC101 Lentivirus Second scFv (DC101)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC506 DC101 Lentivirus Second scFv (DC101)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC507 DC101 Lentivirus Third scFv (DC101)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC508 DC101 Lentivirus Third scFv (DC101)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC616 KDR-1121 Lentivirus Third scFv (KDR-1121)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC617 KDR-1121 Lentivirus Second scFv (KDR-1121)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
CONTACT US

USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
Ringstrasse 4, 64401 Gross-Bieberau, Germany
Tel: 44-207-097-1828

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