The vector of anti-PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PSCA. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-PSCA antibody linked to CD3-zeta signaling domain, as well as a inducible construct compressing MyD88, CD40, and FKBP. The iMC-based CAR-T cells show improved tumor killing and expansion in a rimiducid-dependent manner. And the vector product was designed for the treatment of non-Hodgkin lymphoma.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
|VP-CAR-LC761||Lenti-PSCA CAR (scFv-CD28-41BB-CD3ζ, Ha1-4.117 ) Viral Particle|
|CAR-T-2-L347-4G||Anti-PSCA scFv h(CD4-FcεRIγ) CART, pCDCAR1|
|CAR-T-1-L347-Z||Anti-PSCA scFv h(CD3ζ) CART, pCDCAR1|
|VP-CAR-LC800||Lenti-PSCA CAR (scFv-CD3ζ, AM1) Viral Particle|
|CAR-T-2-L347-4Z||Anti-PSCA scFv h(CD4-CD3ζ) CART, pCDCAR1|
|CAR-MZ037||Anti-PSCA (bm2B3) h(CD28-41BB-CD3ζ) CAR, pCDCAR1|
|CAR-T-3-L347-2BZ||Anti-PSCA scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1|
|VP-CAR-LC758||Lenti-PSCA CAR (scFv-CD28-41BB-CD3ζ, bm2B3) Viral Particle|
|CAR-MZ038||Anti-PSCA (Ha1-4.117 ) h(CD3ζ) CAR, pCDCAR1|
|CAR-MZ091||Anti-PSCA (AM1) h(DAP12) CAR, pCDCAR1|
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