pCDCAR1 PSCA h(28ζ, MyD88)(CAR-LC275)
The vector of anti-PSCA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PSCA. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-PSCA antibody linked to CD3-zeta signaling domain, as well as a inducible construct compressing MyD88, CD40, and FKBP. The iMC-based CAR-T cells show improved tumor killing and expansion in a rimiducid-dependent manner. And the vector product was designed for the treatment of non-Hodgkin lymphoma.
Targeting Cell Type
Discription of Signaling Cassetes
CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD3-zeta to transmit a proliferative/survival signal, or all three can be used together.
prostate stem cell antigen
PSCA; prostate stem cell antigen; PRO232; CD28; Chimeric antigen receptor; T cell; Retrovirus; CARs; Lentivirus; chimeric T cell receptors; chimeric immunoreceptors; chimeric antigen receptors; scFv
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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