CellRapeutics™ Switchable CAR Construction Service

Switchable CAR-T (chimeric antigen receptor T) is an advanced form of CAR-T cell therapy that incorporates a safety switch. Creative Biolabs has introduced a unique CAR T cell, the switchable CAR, which redirects to target new antigens by adding bispecific adaptor proteins.

Switchable CAR: A Unique CAR T Cell

Switchable CAR T cells represent a unique class of engineered immune cells designed to provide additional control over their activity and function. Unlike conventional CAR T cells, which are activated upon encountering a specific antigen and continue to exert their cytotoxic effects until they are depleted, switchable CAR T cells incorporate additional features that allow for modulation of their activity in response to external signals or triggers.

Fig.1 Construction of Switchable CARs.¹

CellRapeutics™ Switchable CAR Construction Service at Creative Biolabs

Creative Biolabs' switchable CAR construction services design, construct, and validate these engineered immune cells based on the customer's specific requirements and goals.

• Project Development Process
  As a professional and rigorous service provider, Creative Biolabs has a complete service process, and we are by your side from the beginning of your project to the delivery of your experimental results.

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• Key Features of Switchable CAR Construction
  Versatile specific programming
  Possess an inherent switch for safe control

Overall, switchable CAR-T is expected to improve the safety of traditional CAR-T therapies and expand their applicability. Creative Biolabs offers this advanced approach to modulating CAR-T cell activity through our comprehensive CAR-T cell platform, which enhances the therapeutic potential of CAR-T while minimizing the associated risks.

What We Can Offer

Successful development of a switchable CAR requires the integration of multiple advanced biotechnology platforms. We offer a comprehensive suite of technologies essential for the analysis, construction, and validation of functional sCAR-T systems:

Process diagram

Final Deliverables include a detailed construct design and vector report, a functional CAR-T cell batch, and a multi-parameter functional validation report.

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Highlights of our Switchable CAR Construction Service

• More versatile, easy to adjust and program
• Significantly reduce the cost of traditional CAR T-cell therapy
• Repeat dosing of bispecific linkers is required
• The safety and effectiveness of the adapter itself should have been verified

Data Display

The following is a presentation of the research results on switchable CARs to help you better understand switchable CARs and the services we can provide.

1. Construction of Switchable CAR-T		2. Functional Assay of Switchable CAR-T
Fig.2 Construction of switchable CAR-T.2	The figure on the left is a schematic diagram of an antibody-based switchable CAR system developed in this study.	Fig.3 CAR-T cells efficiently target PDAC metastasis.2	Fig.3 evaluates the efficacy of CART cells targeting HER2 in a metastatic model. By monitoring tumor development in mice, rapid tumor clearance was observed in the sCAR-T cell + HER2 switch (blue) and conventional HER2 CAR-T cell (green).

Applications of Switchable CAR Construction

Switchable CAR construction offers several applications across the field of immunotherapy and beyond.

Frequently Asked Questions

Q1: When to consider a switchable CAR construction?

A1: Switchable CAR construction should be considered in situations where additional safety features, enhanced specificity, or precise control over CAR T cell activity are desired to improve the safety, efficacy, and applicability of CAR T cell therapy across different disease settings.

As a qualified switchable CAR construction service provider, Creative Biolabs is equipped with the expertise, experience, quality standards and capabilities. If you're looking for help with a switchable CAR construction, choose Creative Biolabs and don't hesitate to contact us.

References

1. Teng, F.; et al. "Programmable synthetic receptors: the next-generation of cell and gene therapies." Sig Transduct Target Ther. (2024).
2. Raj, Deepak et al. "Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma." Gut vol. 68,6 (2019): 1052-1064.