Synthetic T Cell Antigen Receptor (STAR) Design & Construction Service

Chimeric antigen receptor (CAR) T cell therapy has demonstrated high response rates in patients with B-cell malignancies, but remission durability and safety still need to be improved. Creative Biolabs has developed a new type of double-chain chimeric receptor synthetic T cell antigen receptor (STAR). Unlike traditional CARs, STAR has an innovative and patented antigen receptor complex structure. Data have demonstrated that STAR-T products have the advantages of better therapeutic effects but fewer side effects. Moreover, the unique design can be easily developed into multi-target varieties, which effectively improves the survival time of T cells in vivo and reduces the exhaustion of T cells, thereby preventing target escape and tumor recurrence.

Challenges in the Field

Chimeric antigen receptor (CAR) T cell therapy has produced encouraging clinical results, proving their therapeutic potential in mitigating tumour development. However, CAR-T cells express surface receptors that specifically target the surface antigens expressed by cancer cells, which severely limits the development of CAR-T cells in many tumor types. In addition, the targeted surface protein can also be expressed on normal cells, leading to CAR-T-mediated non-cancer killing and potentially life-threatening side effects related to the intensity of the subsequent immune response. To solve the problem of the scope and selectivity of CAR-T, researchers are turning to a method of engineering T cells based on the T cell receptor (TCR-T). TCR selectively recognize target cells comes from its unique ability to recognize cell surface "antigens". These antigens can be used as selective identifiers for malignant cells, and more and more tumor-related antigens have been identified so that effective and selective TCR-Ts can be designed for cancer. Various TCR-T products that have been developed have shown safe and positive therapeutic effects in clinical studies.

STAR-T cell therapy combines the advantages of CAR-T and TCR-T therapy, fusing two scFv antibodies to the α chain and β chain of TCR respectively. Therefore, STAR-T scFv is designed to target the surface antigen of cancer cells (similar to CAR), but at the same time retain the natural activation signal of TCR (similar to TCR).

Features of STAR-T

• Innovated structure with series of PCT patents
• Functioned better with improved T cell expansion and reduced T cell depletion
• Easily derived to multi-target forms for preventing tumor recurrence due to target escape
• Infiltrated into solid tumor more efficiently
• Clinical safety and efficacy confirmed

STAR Design and Construction Services at Creative Biolabs

Empowered by the advanced Smart™ CAR development platform, Creative Biolabs is capable of providing STAR CAR design and construction services. In addition to designing and cloning the classic CARs (1rd-4rd), we also provide multiple next-generation CAR vector products, such as synnotch CAR，universal CAR, overexpressed CAR, and switch CAR, etc. As the leading cell therapeutics biotech, Creative Biolabs masters the most advanced technology and has a very rich extensive experience and thus can ensure the best quality of CAR vector products.

For more detailed information, please feel free to contact us or directly sent us an inquiry.

What We Can Offer

Our service is built upon a foundation of established and innovative technology platforms designed for efficiency and quality. Our services include:

Service Workflow

Our workflow is a comprehensive, step-by-step process designed for transparency and efficiency, ensuring a successful outcome for your project.

Discover How We Can Help - Request a Consultation

Key Benefits

• Tailored STAR Design: Our STAR design and construction service is highly customizable, allowing for precise engineering of the receptor to target your specific antigen and desired therapeutic response.
• Efficient Process Development: Our integrated platforms for gene synthesis, vector construction, and viral packaging ensure high efficiency and quality throughout the upstream and downstream process development.
• Robust Quality Systems: We adhere to a well-established quality management system and employ rigorous quality control checks at every stage, from DNA sequencing to functional validation, guaranteeing the stability and consistency of your product.

FAQs

Related Services

To help you achieve your overall research goals, we offer several complementary services that can be integrated with your STAR project.

Why Choose Us?

Creative Biolabs' Synthetic T Cell Antigen Receptor (STAR) Design and Construction Service provides a robust and innovative solution to the challenges of solid tumor immunotherapy. By combining advanced engineering with native T-cell signaling, we help you develop a next-generation therapeutic candidate with superior performance and reduced risk of T-cell exhaustion.

Our team of expert scientists is ready to discuss your project in detail and provide a customized solution. We are committed to helping you accelerate your research and bring more effective treatments to the market. Contact our team for more information and to discuss your project.