APP

All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. APP gene contains 19 exons and spans more than 170 kb. APP has several isoforms generated by alternative splicing of exons 1-13, 13a, and 14-18. The predominant transcripts are APP695 (exons 1-6, 9-18, not 13a), APP751 (exons 1-7, 9-18, not 13a), and APP770 (exons 1-18, not 13a). Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
XS-1022-ZP612 Anti-APP (9TL) h(CD28-CD3ζ) CAR, pCDCAR4 Human 9TL Mouse scFv-CD28-CD104ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP613 Anti-APP (WO2) h(41BB-CD3ζ) CAR, pCDCAR5 Human WO2 Mouse scFv-41BB-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP614 Anti-APP (WO2) h(CD28-CD3ζ) CAR, pCDCAR5 Human WO2 Mouse scFv-CD28-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP615 Anti-APP (2E11) h(41BB-CD3ζ) CAR, pCDCAR6 Human 2E11 Mouse scFv-41BB-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP616 Anti-APP (2E11) h(CD28-CD3ζ) CAR, pCDCAR6 Human 2E11 Mouse scFv-CD28-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP617 Anti-APP (1D1) h(41BB-CD3ζ) CAR, pCDCAR7 Human 1D1 Mouse scFv-41BB-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP618 Anti-APP (1D1) h(41BB-CD3ζ) CAR, pCDCAR4 Human 1D1 Mouse scFv-CD28-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP619 Anti-APP (2B3) h(CD28-CD3ζ) CAR, pCDCAR4 Human 2B3 Mouse scFv-41BB-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP620 Anti-APP (2B3) h(41BB-CD3ζ) CAR, pCDCAR5 Human 2B3 Mouse scFv-CD28-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP621 Anti-APP (5C9) h(CD28-CD3ζ) CAR, pCDCAR5 Human 5C9 Mouse scFv-41BB-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP622 Anti-APP (5C9) h(41BB-CD3ζ) CAR, pCDCAR6 Human 5C9 Mouse scFv-CD28-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP623 Anti-APP (ch2.1) h(CD28-CD3ζ) CAR, pCDCAR6 Human ch2.1 Chimeric scFv-41BB-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP624 Anti-APP (ch2.1) h(41BB-CD3ζ) CAR, pCDCAR7 Human ch2.1 Chimeric scFv-CD28-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP625 Anti-APP (m21F12) h(CD28-CD3ζ) CAR, pCDCAR7 Human m21F12 Mouse scFv-41BB-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP626 Anti-APP (m21F12) h(41BB-CD3ζ) CAR, pCDCAR8 Human m21F12 Mouse scFv-CD28-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP627 Anti-APP (m4c9) h(41BB-CD3ζ) CAR, pCDCAR5 Human m4c9 Mouse scFv-41BB-CD108ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP628 Anti-APP (m4c9) h(CD28-CD3ζ) CAR, pCDCAR5 Human m4c9 Mouse scFv-CD28-CD108ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP629 Anti-APP (NI-103) h(41BB-CD3ζ) CAR, pCDCAR6 Human NI-103 Human scFv-41BB-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP630 Anti-APP (NI-103) h(CD28-CD3ζ) CAR, pCDCAR6 Human NI-103 Human scFv-CD28-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP631 Anti-APP (AD64) h(41BB-CD3ζ) CAR, pCDCAR7 Human AD64 Human scFv-41BB-CD108ζ Lentiviral vector T cell   Add to Cart   Datasheet
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