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APP

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This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. APP gene contains 19 exons and spans more than 170 kb. APP has several isoforms generated by alternative splicing of exons 1-13, 13a, and 14-18. The predominant transcripts are APP695 (exons 1-6, 9-18, not 13a), APP751 (exons 1-7, 9-18, not 13a), and APP770 (exons 1-18, not 13a). Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
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CAT Product Name Target Species Antibody Clone Antibody Host Receptor Construction Vector Type Targeting Cell Type CAR Vector Type Inquiry & Datasheet
CAR-CN382 Anti-APP (12B4) h(41BB-CD3ζ) CAR, pCDCAR1 Human 12B4 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN383 Anti-APP (2C1) h(41BB-CD3ζ) CAR, pCDCAR1 Human 2C1 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN384 Anti-APP (12A11) h(41BB-CD3ζ) CAR, pCDCAR1 Human 12A11 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN385 Anti-APP (3A3) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3A3 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
CAR-CN386 Anti-APP (3D6) h(41BB-CD3ζ) CAR, pCDCAR1 Human 3D6 Mouse scFv-41BB-CD3ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP612 Anti-APP (9TL) h(CD28-CD3ζ) CAR, pCDCAR4 Human 9TL Mouse scFv-CD28-CD104ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP613 Anti-APP (WO2) h(41BB-CD3ζ) CAR, pCDCAR5 Human WO2 Mouse scFv-41BB-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP614 Anti-APP (WO2) h(CD28-CD3ζ) CAR, pCDCAR5 Human WO2 Mouse scFv-CD28-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP615 Anti-APP (2E11) h(41BB-CD3ζ) CAR, pCDCAR6 Human 2E11 Mouse scFv-41BB-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP616 Anti-APP (2E11) h(CD28-CD3ζ) CAR, pCDCAR6 Human 2E11 Mouse scFv-CD28-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP617 Anti-APP (1D1) h(41BB-CD3ζ) CAR, pCDCAR7 Human 1D1 Mouse scFv-41BB-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP618 Anti-APP (1D1) h(41BB-CD3ζ) CAR, pCDCAR4 Human 1D1 Mouse scFv-CD28-CD105ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP619 Anti-APP (2B3) h(CD28-CD3ζ) CAR, pCDCAR4 Human 2B3 Mouse scFv-41BB-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP620 Anti-APP (2B3) h(41BB-CD3ζ) CAR, pCDCAR5 Human 2B3 Mouse scFv-CD28-CD106ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP621 Anti-APP (5C9) h(CD28-CD3ζ) CAR, pCDCAR5 Human 5C9 Mouse scFv-41BB-CD107ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP678 Anti-APP (AD38) h(41BB-CD3ζ) CAR, pCDCAR13 Human AD38 Human scFv-CD28-CD115ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP679 Anti-APP (4D3) h(CD28-CD3ζ) CAR, pCDCAR13 Human 4D3 Human scFv-41BB-CD116ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP680 Anti-APP (4D3) h(41BB-CD3ζ) CAR, pCDCAR14 Human 4D3 Human scFv-CD28-CD116ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP681 Anti-APP (1C9) h(41BB-CD3ζ) CAR, pCDCAR11 Human 1C9 Human scFv-41BB-CD117ζ Lentiviral vector T cell   Add to Cart   Datasheet
XS-1022-ZP682 Anti-APP (1C9) h(CD28-CD3ζ) CAR, pCDCAR11 Human 1C9 Human scFv-CD28-CD117ζ Lentiviral vector T cell   Add to Cart   Datasheet
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