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HBV

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.

Associated Disease
  • Cirrhosis;
  • hepatocellular carcinoma (HCC);
  • liver cancer
  • Hepatoblastoma
  • CAR Vector Products
  • TCR Vector Products
  • CAR Viral Particles
  • TCR Viral Particles
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  • Receptor Construction:
CAT Product Name Target SpeciesAntibody CloneAntibody HostReceptor ConstructionVector TypeTargeting Cell Type Inquiry & Datasheet
CAR-T-1-M319-2 Anti-HBV S protein scFv h(CD28) CART, pCDCAR1 Human S 26 Mouse scFv-CD28 Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-M319-G Anti-HBV S protein scFv h(FcεRIγ) CART, pCDCAR1 Human S 26 Mouse scFv-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-1-M319-Z Anti-HBV S protein scFv h(CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-2G Anti-HBV S protein scFv h(CD28-FcεRIγ) CART, pCDCAR1 Human S 26 Mouse scFv-CD28-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-2Z Anti-HBV S protein scFv h(CD28-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD28-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-4G Anti-HBV S protein scFv h(CD4-FcεRIγ) CART, pCDCAR1 Human S 26 Mouse scFv-CD4-FcεRIγ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-4Z Anti-HBV S protein scFv h(CD4-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD4-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-8Z Anti-HBV S protein scFv h(CD8-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD8-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-BZ Anti-HBV S protein scFv h(41BB-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-2-M319-CZ Anti-HBV S protein scFv h(b2c-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-b2c-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-M319-2BZ Anti-HBV S protein scFv h(CD28-41BB-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD28-41BB-CD3ζ Lentiviral T cell   Inquiry
  Datasheet
CAR-T-3-M319-2XZ Anti-HBV S protein scFv h(CD28-OX40-CD3ζ) CART, pCDCAR1 Human S 26 Mouse scFv-CD28-OX40-CD3ζ Lentiviral T cell   Inquiry
  Datasheet

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