HBV

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.

Associated Disease
  • Cirrhosis;
  • hepatocellular carcinoma (HCC);
  • liver cancer
  • Hepatoblastoma

CAR Vector Products Product list:

Catalog Targeting
Cell Type
Generation Antibody
Clone
Vector
Length
Vector
Type
Vector Design Antibody
Host
Data
sheet
Price
CAR-T-1-M319-2 T cell First S 26 8kb Lentiviral scFv-CD28 Mouse Inquiry
CAR-T-1-M319-G T cell First S 26 8kb Lentiviral scFv-FcεRIγ Mouse Inquiry
CAR-T-1-M319-Z T cell First S 26 8kb Lentiviral scFv-CD3ζ Mouse Inquiry
CAR-T-2-M319-2G T cell Second S 26 8kb Lentiviral scFv-CD28-FcεRIγ Mouse Inquiry
CAR-T-2-M319-2Z T cell Second S 26 8kb Lentiviral scFv-CD28-CD3ζ Mouse Inquiry
CAR-T-2-M319-4G T cell Second S 26 8kb Lentiviral scFv-CD4-FcεRIγ Mouse Inquiry
CAR-T-2-M319-4Z T cell Second S 26 8kb Lentiviral scFv-CD4-CD3ζ Mouse Inquiry
CAR-T-2-M319-8Z T cell Second S 26 8kb Lentiviral scFv-CD8-CD3ζ Mouse Inquiry
CAR-T-2-M319-BZ T cell Second S 26 8kb Lentiviral scFv-41BB-CD3ζ Mouse Inquiry
CAR-T-2-M319-CZ T cell Second S 26 8kb Lentiviral scFv-b2c-CD3ζ Mouse Inquiry
CAR-T-3-M319-2BZ T cell Third S 26 8kb Lentiviral scFv-CD28-41BB-CD3ζ Mouse Inquiry
CAR-T-3-M319-2XZ T cell Third S 26 8kb Lentiviral scFv-CD28-OX40-CD3ζ Mouse Inquiry

TCR Vector Products Product list:

Catalog Target Target
Species
Antibody
Clone
scFv-Host
Animal
Vector
length
Vector
Type
Epitope Format HLA Data
sheet
Price
TCR-L039Z HBV HBV Human 8kb Lentiviral FLPSDFFPSV Non-modified HLA-A2 Inquiry
TCR-L040Z HBV HBV Human 8kb Lentiviral FLGPLLVLQA Cysteine-modified HLA-Cw0801 Inquiry
TCR-L041 HBV HBV Human 3817bp retroviral vector FLGPLLVLQA Cysteine-modified TCR HLA-Cw0801 Inquiry
TCR-L041Z HBV HBV Human 8kb Lentiviral FLPSDFFPSV Cysteine-modified HLA-A0201 Inquiry
TCR-L042 HBV HBV Human 3817bp retroviral vector FLPSDFFPSV Cysteine-modified TCR HLA-A0201 Inquiry
TCR-L042Z HBV HBV Human 8kb Lentiviral SIVSPFIPLL Cysteine-modified HLA-A0201 Inquiry
TCR-L043 HBV HBV Human 3817bp retroviral vector SIVSPFIPLL Cysteine-modified TCR HLA-A0201 Inquiry
TCR-L043Z HBV HBV Human 8kb Lentiviral FLLTRILTI Cysteine-modified HLA-A0201 Inquiry
TCR-L044 HBV HBV Human 3817bp retroviral vector FLLTRILTI Cysteine-modified TCR HLA-A0201 Inquiry
TCR-L045 HBV HBV Human 3817bp retroviral vector FLPSDFFPSV Non-modified TCR HLA-A0201 Inquiry
TCR-L046 HBV HBV Human 6700-8070bp retroviral vector FLPSDYFPSV Non-modified TCR HLA-A2 Inquiry

CAR Viral Particles Product list:

Catalog Antibody
Clone
Packaging
System
Generation Gene
Construct
Promotor Packaging
Cell
Titer Data
sheet
Price
VP-CAR-LC449 S 26 Lentivirus First scFv (S26)-CD28 CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC450 S 26 Lentivirus First scFv (S26)-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC451 S 26 Lentivirus First scFv (S26)-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC452 S 26 Lentivirus Second scFv (S26)-CD28-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC453 S 26 Lentivirus Second scFv (S26)-CD28-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC454 S 26 Lentivirus Second scFv (S26)-CD4-FcεRIγ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC455 S 26 Lentivirus Second scFv (S26)-CD4-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC456 S 26 Lentivirus Second scFv (S26)-CD8-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC457 S 26 Lentivirus Second scFv (S26)-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC458 S 26 Lentivirus Second scFv (S26)-b2c-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC459 S 26 Lentivirus Third scFv (S26)-CD28-41BB-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry
VP-CAR-LC460 S 26 Lentivirus Third scFv (S26)-CD28-OX40-CD3ζ CMV 293T > 10⁷ IFU/ml Inquiry

TCR Viral Particles Product list:

Catalog Target
Species
Antibody
Clone
scFv-Host
Animal
Packaging
System
Epitope Format Titer Data
sheet
Price
VP-TCR-C182 HBV Human Lentivirus FLGPLLVLQA Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C183 HBV Human Lentivirus FLPSDFFPSV Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C184 HBV Human Lentivirus SIVSPFIPLL Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C185 HBV Human Lentivirus FLLTRILTI Cysteine-modified TCR > 10⁷ IFU/ml Inquiry
VP-TCR-C186 HBV Human Lentivirus FLPSDFFPSV Non-modified TCR > 10⁷ IFU/ml Inquiry
CONTACT US

USA
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Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

Europe
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Tel: 44-207-048-3343

Distributors

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