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IE-1

Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters.

Associated Disease
  • Cytomegalovirus infection
  • TCR Vector Products
  • TCR Viral Particles
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    CAT Product Name Target SpeciesAntibody CloneAntibody HostEpitopeHLAVector Type Inquiry & Datasheet
    TCR-C102Z Human anti-IE-1 T cell receptor, pCDTCR1 CMV Human ELRRKMMYM HLA-B8 Lentiviral   Add to Cart   Datasheet

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