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Anti-IE-1 T cell receptor, pCDTCR1 (TCR-C102Z)

The vector of anti-IE-1 T cell receptor (TCR) is constructed for the engineering of T cell to target CMV IE-1. The T cells are genetically modified through transduction with a lentiviral vector expressing IE-1-specific T cell receptor. And the vector product was designed for the treatment of Cytomegalovirus infection.

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Details

  • Target
  • IE-1
  • Target Species
  • CMV
  • Epitope
  • ELRRKMMYM
  • Format
  • Non-modified
  • HLA
  • HLA-B8
  • Targeting Diseases
  • Cytomegalovirus infection
  • Vector Name
  • pCDTCR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral
  • TCR Host Animal
  • Human

Target

  • Official Symbol
  • IE-1
  • Introduction
  • Plays an important role in transactivating viral early genes as well as activating its own promoter. Targets and disrupts host PML/nuclear domain 10 (ND10). Promotes efficient viral growth by interacting with and directing host SP100 to degradation, leading to enhanced acetylation level of histones. In addition, functions in counteracting the host innate antiviral response. Inhibits the type I interferon pathway by directly interacting with and sequestrating host STAT2. Alters host cell cycle progression, probably through its interaction with host E2F1 or RB1 that overcomes the RB1-mediated repression of E2F-responsive promoters.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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